Results 161 to 170 of about 21,994 (199)
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Diagnostic Microbiology and Infectious Disease, 2007
Shiga toxins (Stx) are believed to play a key role in the pathogenesis of diseases caused by Stx-producing Escherichia coli (STEC), including the potentially life-threatening hemolytic uremic syndrome (HUS). In this study, 201 STEC strains collected from patients and environmental sources were investigated with regard to the stx genotypes and ...
Dorothea, Orth +5 more
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Shiga toxins (Stx) are believed to play a key role in the pathogenesis of diseases caused by Stx-producing Escherichia coli (STEC), including the potentially life-threatening hemolytic uremic syndrome (HUS). In this study, 201 STEC strains collected from patients and environmental sources were investigated with regard to the stx genotypes and ...
Dorothea, Orth +5 more
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Human Milk Contains the Shiga Toxin and Shiga-like Toxin Receptor Glycolipid Gb3
The Journal of Infectious Diseases, 1992Human milk antibody and nonantibody factors are thought to be important in protecting infants from diarrheal diseases. The nonantibody factors include host receptor analogues that bind to specific pathogen virulence factors, thereby inhibiting these bacterial products from binding to their intestinal target receptors.
D S, Newburg, S, Ashkenazi, T G, Cleary
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2000
Abstract Shigellosis in children (rarely in adults) is often associated with lethargy, seizures, and headache; shiga toxin, produced by strains of Shigella dysenteriae type 1, has been considered responsible for these effects (1). Shiga toxin is a representative of a larger family of toxins (verotoxins) produced by ...
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Abstract Shigellosis in children (rarely in adults) is often associated with lethargy, seizures, and headache; shiga toxin, produced by strains of Shigella dysenteriae type 1, has been considered responsible for these effects (1). Shiga toxin is a representative of a larger family of toxins (verotoxins) produced by ...
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Affinity purification of Shiga-like toxin I and Shiga-like toxin II
Journal of Microbiological Methods, 1998Abstract A facile method is described for affinity purifying Shiga-like toxin I (verotoxin 1) or Shiga-like toxin II (verotoxin 2) from cell-free Escherichia coli culture supernatant solutions using immobilized synthetic analogs of the digalactoside [αGal(1,4)βGal] host cell receptor for these toxins.
George L Mulvey, Glen D Armstrong
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Antibodies to Shiga toxins in Brazilian cattle
Toxicon, 2017Cattle are considered a reservoir of Shiga toxin-producing Escherichia coli (STEC). There is no information about the presence of antibodies against Shiga toxins in Brazilian bovine serum. Using ELISA, all sera tested showed antibodies against the two main STEC virulence factors; Stx1 and Stx2.
Bruno B, Yamamoto +6 more
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Detection Methods for Shiga Toxins and Shiga Toxin-Producing E. coli
2017Shiga toxin detection methods reflect the complicated biological processes that deliver these toxins to their target cells. Some detection methods employ techniques that indirectly detect the presence of Shiga toxins. Microbiological methods are used to identify pathogenic serotypes of E. coli, such as the infamous O157:H7, but the potential production
Christopher J. Silva +3 more
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Effect of Shiga toxins on granulocyte function
Microbial Pathogenesis, 2002We already showed that injection of Shiga toxin (Stx) 2 into mice caused severe granulocytosis in the peripheral blood. In this study we further clarified changes of granulocyte function by Stx 2. The activity of medullasin, a neutral serine protease in granulocytes that injures endothelial cells in vessels, significantly increased when Stx 2 was ...
Yosuke, Aoki, Tac, Takeda
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Shiga Toxin: Purification, Structure, and Function
Clinical Infectious Diseases, 1991Shiga toxin is a potent toxin produced by Shigella dysenteriae type 1 strains. The toxin has three biologic activities--cytotoxicity, enterotoxicity, and neurotoxicity--and one known biochemical effect: inhibition of protein synthesis. It consists of two polypeptide chains, an A chain (molecular weight, 32,225) and a B chain (molecular weight, 7,691 ...
A, Donohue-Rolfe +2 more
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Interaction of Shiga Toxin with Endothelial Cells
2003Item does not contain ...
Bitzan, M., Loo, D.M.W.M. te
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Mode of Action of Shiga and Shiga-Like Toxins
1990Enterohemorrhagic Escherichia coli 0157:H7 and other serotypes produce at least two distinct cytotoxins that affect Vero cells (Vero toxins).9,14,15,17 Both Vero toxins have been purified to homogeneity and the properties of the purified toxins have been examined extensively.9,17 One of them was found to be identical to Shiga toxin in molecular ...
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