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Shiga Toxin Producing Escherichia coli
Clinics in Laboratory Medicine, 2015Shiga toxin-producing Escherichia coli (STEC) is among the common causes of foodborne gastroenteritis. STEC is defined by the production of specific toxins, but within this pathotype there is a diverse group of organisms. This diversity has important consequences for understanding the pathogenesis of the organism, as well as for selecting the optimum ...
Allen, Bryan +2 more
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Detection Methods for Shiga Toxins and Shiga Toxin-Producing E. coli
, 2017Shiga toxin detection methods reflect the complicated biological processes that deliver these toxins to their target cells. Some detection methods employ techniques that indirectly detect the presence of Shiga toxins. Microbiological methods are used to identify pathogenic serotypes of E. coli, such as the infamous O157:H7, but the potential production
Christopher J. Silva +3 more
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Shiga toxin-producing Escherichia coli
Current Infectious Disease Reports, 1999Shiga toxin-producing Escherichia coli (STEC) are emerging as a significant source of foodborne infectious disease in the developed world. Multistate outbreaks of E. coli O157 and non-O157 serogroups in the United States are facilitated by the centralization of food processing and distribution.
, Jaeger, , Acheson
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Protection of Monkeys against Shiga Toxin Induced by Shiga Toxin-Liposome Conjugates
International Archives of Allergy and Immunology, 2002<i>Background:</i> We previously reported that the purified Shiga toxins (Stx) Stx1 and Stx2, when coupled with liposomes, induced substantial production of anti-Stx1 and anti-Stx2 IgG antibody, respectively, in mice. The levels of anti-Stx antibody in the sera of mice immune to Stx-liposome correlated well with the protection against ...
Yuriko, Suzaki +14 more
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Shiga-toxin-converting bacteriophages
Research in Microbiology, 2001Shiga toxins (Stx) comprise a family of potent cytotoxins that are involved in severe human disease. Stx are mainly produced by Escherichia coli isolated from human and nonhuman sources, and by Shigella dysenteriae type 1. The genes encoding Stx are thought to be generally encoded in the genome of lambdoid prophages (Stx-converting bacteriophages; Stx ...
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Human Milk Contains the Shiga Toxin and Shiga-like Toxin Receptor Glycolipid Gb3
The Journal of Infectious Diseases, 1992Human milk antibody and nonantibody factors are thought to be important in protecting infants from diarrheal diseases. The nonantibody factors include host receptor analogues that bind to specific pathogen virulence factors, thereby inhibiting these bacterial products from binding to their intestinal target receptors.
D S, Newburg, S, Ashkenazi, T G, Cleary
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Shiga Toxin-Producing Escherichia coli
2014In the United States, it is estimated that non-O157 Shiga toxin-producing Escherichia coli (STEC) cause more illnesses than STEC O157:H7, and the majority of cases of non-O157 STEC infections are due to serogroups O26, O45, O103, O111, O121, and O145, referred to as the top six non-O157 STEC.
James L, Smith +2 more
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Shiga Toxin: Purification, Structure, and Function
Clinical Infectious Diseases, 1991Shiga toxin is a potent toxin produced by Shigella dysenteriae type 1 strains. The toxin has three biologic activities--cytotoxicity, enterotoxicity, and neurotoxicity--and one known biochemical effect: inhibition of protein synthesis. It consists of two polypeptide chains, an A chain (molecular weight, 32,225) and a B chain (molecular weight, 7,691 ...
A, Donohue-Rolfe +2 more
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Entry of Shiga Toxin into Cells
Zentralblatt für Bakteriologie, 1993The effect of Shiga toxin with mutations in the A fragment has been tested on cells in order to get more information about the processing of the A fragment during entry into the cytosol. A mutant with a deletion between the A1 and A2 domain in the A fragment is resistant to cleavage by trypsin and is less toxic than wild type toxin on both Vero and ...
Sandvig, Kirsten +6 more
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Phage display and Shiga toxin neutralizers
Toxicon, 2016The current work presents an overview of the use of phage display technology for the identification and characterization of potential neutralizing agents for Shiga toxins. The last major Shiga toxin-associated disease outbreak, which took place in Germany in 2011, showed the international community that Shiga toxins remain a serious threat to public ...
Robert Alvin, Bernedo-Navarro +1 more
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