Results 21 to 30 of about 177,811 (299)

Towards a Four-Component GMMA-Based Vaccine against Shigella

Vaccines, 2022
Shigellosis remains a major public health problem around the world; it is one of the leading causes of diarrhoeal disease in low- and middle-income countries, particularly in young children.
F. Micoli, U. Nakakana, F. Berlanda Scorza   +2 more
semanticscholar   +1 more source

Pathogenomic analyses of Shigella isolates inform factors limiting shigellosis prevention and control across LMICs

Nature Microbiology, 2022
Shigella spp. are the leading bacterial cause of severe childhood diarrhoea in low- and middle-income countries (LMICs), are increasingly antimicrobial resistant and have no widely available licenced vaccine.
Rebecca J. Bengtsson, A. Simpkin, C. Pulford, Ross Low, D. Rasko, D. Rigden, N. Hall, E. Barry, S. Tennant, K. Baker   +9 more
semanticscholar   +1 more source

Burden of Shigella in South Asia: a systematic review and meta-analysis.

Journal of Travel Medicine, 2022
BACKGROUND Shigella remains one of the most common causes of diarrhoea in South Asia. Current estimates of the prevalence of Shigella are critical for guiding control measures. We estimated the prevalence of Shigella species and serogroups in South Asia.
B. A. Muzembo, Kei Kitahara, D. Mitra, Ayumu Ohno, Januka Khatiwada, S. Dutta, S. Miyoshi   +6 more
semanticscholar   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

The Shigella Type III Secretion System: An Overview from Top to Bottom

Microorganisms, 2021
Shigella comprises four species of human-restricted pathogens causing bacillary dysentery. While Shigella possesses multiple genetic loci contributing to virulence, a type III secretion system (T3SS) is its primary virulence factor.
M. Muthuramalingam, Sean K Whittier, W. Picking, W. Picking   +3 more
semanticscholar   +1 more source

Epidemiology of Shigella-Associated diarrhea in Gorgan, north of Iran [PDF]

, 2007
Objective : Shigella is an important etiological agent for diarrhea and especially dysentery. Shigellosis is an intestinal infection that is a major public health problem in many developing countries.
Ahmadi, A.R., Aslani, M.M., Dadgar, T., Ghaemi, E.O., Livani, S., Mansourian, A.R., Moradi, A.V., Nosrat, S.B.   +7 more
core   +1 more source

Characterization of an emergent clone of enteroinvasive Escherichia coli circulating in Europe [PDF]

, 2016
Enteroinvasive Escherichia coli (EIEC) cause intestinal illness indistinguishable from that caused by Shigella, mainly in developing countries. Recently an upsurge of cases of EIEC infections has been observed in Europe, with two large outbreaks ...
Caprioli, A., Dallman, T., Herrera León, S., Jenkins, C., Maugliani, A., Michelacci, V, Morabito, S., PROSSEDA, Gianni, Sanchez, S., Tozzoli, R.   +9 more
core   +1 more source

Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990–2016

Lancet. Infectious Diseases (Print), 2018
Summary Background Shigella and enterotoxigenic Escherichia coli (ETEC) are bacterial pathogens that are frequently associated with diarrhoeal disease, and are a significant cause of mortality and morbidity worldwide.
I. Khalil, C. Troeger, B. Blacker, P. Rao, Alexandria Brown, D. Atherly, T. Brewer, Cyril Engmann, Cyril Engmann, E. Houpt, G. Kang, K. Kotloff, M. Levine, S. Luby, C. MacLennan, W. Pan, P. Pavlinac, J. Platts-Mills, F. Qadri, M. Riddle, E. Ryan, D. Shoultz, A. Steele, J. Walson, J. Sanders, A. Mokdad, C. Murray, Simon Iain Hay, R. Reiner   +28 more
semanticscholar   +1 more source

The emergence and fate of horizontally acquired genes in Escherichia coli [PDF]

, 2008
Bacterial species, and even strains within species, can vary greatly in their gene contents and metabolic capabilities. We examine the evolution of this diversity by assessing the distribution and ancestry of each gene in 13 sequenced isolates of ...
Passel, M.W.J., van, Marri, P.R., Ochman, H.   +2 more
core   +2 more sources

Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump. [PDF]

, 2020
The efflux pumps from the Resistance-Nodulation-Division family, RND, are main contributors to intrinsic antibiotic resistance in Gram-negative bacteria. Among this family, the MdtABC pump is unusual by having two inner membrane components.
Górecki, Kamil, McEvoy, Megan M
core   +2 more sources