Results 21 to 30 of about 19,422 (137)

Shigella sonnei O-Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation

mBio, 2019
Two Shigella species, Shigella flexneri and Shigella sonnei, cause approximately 90% of bacterial dysentery worldwide. While S. flexneri is the dominant species in low-income countries, S.
Jayne L. Watson, Julia Sanchez-Garrido, Philippa J. Goddard, Vincenzo Torraca, Serge Mostowy, Avinash R. Shenoy, Abigail Clements   +6 more
doaj   +1 more source

Dominant serotype distribution and antimicrobial resistance profile of Shigella spp. in Xinjiang, China.

PLoS ONE, 2018
Shigella represents one of the major diarrhea-inducing pathogens threatening public health, but its prevalence and antimicrobial resistance profile in Xinjiang Uygur Autonomous region, China, remains unclear.
Hongbo Liu, Binghua Zhu, Shaofu Qiu, Yidan Xia, Beibei Liang, Chaojie Yang, Nian Dong, Yongrui Li, Ying Xiang, Shan Wang, Jing Xie, Muti Mahe, Yansong Sun, Hongbin Song   +13 more
doaj   +1 more source

Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.

PLoS ONE, 2021
IntroductionShigellosis, is a leading cause of moderate-to-severe diarrhoea and related mortality in young children in low and middle income countries (LMICs).
Caroline C Chisenga, Samuel Bosomprah, Michelo Simuyandi, Katayi Mwila-Kazimbaya, Obvious N Chilyabanyama, Natasha M Laban, Anya Bialik, Valeria Asato, Shiri Meron-Sudai, Gad Frankel, Daniel Cohen, Roma Chilengi   +11 more
doaj   +1 more source

Exploring the Sit-and-Wait Potential of the Bacterial Pathogen Shigella flexneri: A Comparative Genomic Study

Biology and Life Sciences Forum, 2023
The sit-and-wait hypothesis predicts that bacterial durability in the external environment is positively correlated with the evolution of bacterial virulence.
Bin Gu, Jun-Jiao Wang, Xin-Lei Huang, Quan Yuan, Khashayar Shahin, Huan Yang, Fen Li, Liang Wang   +7 more
doaj   +1 more source

Molecular Detection of BlaSHV and Sul2 Genes in Multidrug-Resistant Shigella flexneri from Clinical Specimens in North-East Nigeria

UMYU Scientifica Journal
The continued detection and dissemination of multidrug-resistant (MDR) Shigella species pose a significant public health threat worldwide, especially in resource-limited regions such as the Northeast, Nigeria.
Yunusa Saheed, Inusa Titus, Mahmud Yerima Iliyasu, Ahmed Farouk Umar   +3 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Finding potential drug targets against Shigella flexneri through druggable proteome exploration.

Frontiers in Microbiology, 2016
:Background: Shigella flexneri is a gram negative bacteria that causes the infectious disease ‘shigellosis’. Shigella flexneri (S. flexneri) is responsible for developing diarrhea, fever and stomach cramps in human.
Mohammad Uzzal Hossain, Md. Arif Khan, Abu Hashem, Md. Monirul Islam, Mohammad Neaz Morshed, Chaman Ara Keya, Md. Salimullah   +6 more
doaj   +1 more source

Polycationic Peptide Engineering of Phage Endolysins Expands Host Range and Enhances Antibacterial and Antibiofilm Activities Against Bacillus Species

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The exponential rise in antimicrobial resistance has highlighted the urgent need for the development of alternative antibacterial strategies, including phage‐derived and engineered protein agents such as endolysins and artilysins. In this study, we report the rational design, expression, and functional characterization of novel artilysins ...
Farhat Ansari, Tarushi, Vandan Nagar
wiley   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, EarlyView.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source