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Pathogenicity and virulence of Shigella sonnei : A highly drug-resistant pathogen of increasing prevalence [PDF]

Virulence, 2023
Shigella spp. are the causative agent of shigellosis (or bacillary dysentery), a diarrhoeal disease characterized for the bacterial invasion of gut epithelial cells.
Xosé M Matanza, Abigaïl Clements
exaly   +4 more sources

Genome-wide analysis exploring mechanisms used by Shigella sonnei to survive long-term nutrient starvation [PDF]

mSystems
Shigella is a major cause of severe diarrhea, with Shigella flexneri and Shigella sonnei accounting for over 90% of infections. Progressive economic growth worldwide correlates with the replacement of S. flexneri by S.
Xosé M. Matanza, P. Brian Leung, Vincenzo Torraca, Jayne Watson, Matthew J. Dorman, Nicholas R. Thomson, Abigail Clements   +6 more
doaj   +2 more sources

Macrolide-Resistant Shigella sonnei

Emerging Infectious Diseases, 2008
Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2′-phosphotransferase that inactivates macrolides ...
Leyla Boumghar-Bourtchai, Patricia Mariani-Kurkdjian, Edouard Bingen, Ingrid Filliol, Anne Dhalluin, Shadia Ait Ifrane, François-Xavier Weill, Roland Leclercq   +7 more
doaj   +5 more sources

Shigella flexneri and Shigella sonnei among children under five in Kenya’s urban informal settlement [PDF]

Gut Pathogens
Background Shigella species are a significant global public health threat with the highest burden of Shigella-associated diarrhoea in children under five years of age, particularly in low- and middle-income countries. Given the high burden of shigellosis
Christine Kioko, John M. Maingi, Cecilia Mbae, Phelgona Otieno, Collins Kebenei, Winfred Mbithi, Amos Njuguna, Schola Kamwethya, Diana Imoli, Darius Ideke, Jessicah Jepchirchir, Kelvin Kering, Samuel Kariuki   +12 more
doaj   +2 more sources

Shigella sonnei: virulence and antibiotic resistance [PDF]

Archives of Microbiology, 2020
Shigella sonnei is the emerging pathogen globally, as it is the second common infectious species of shigellosis (bloody diarrhoea) in low- and middle-income countries (LMICs) and the leading one in developed world. The multifactorial processes and novel mechanisms have been identified in S. sonnei, that are collectively playing apart a substantial role
Ahtesham Ahmad Shad
exaly   +3 more sources

Extended spectrum β-lactamase and integron genes among Shigella flexneri and Shigella sonnei isolated from children with diarrhea in shiraz, Southwest Iran [PDF]

BMC Pediatrics
Shigellosis, a bacterial infection marked by dysentery, is typically a self-limiting disease and can be effectively managed with oral rehydration. However, antibiotics may help reduce the severity and duration of Shigellosis despite rising antimicrobial ...
Keyvan Farhadi, Abolfazl Rafati Zomorodi, Mohammadhassan Hassannezhad, Samane Mohebi, Mohammad Motamedifar, Leila Kasraian   +5 more
doaj   +2 more sources

THE SPECIFIC ANTIGENS OF VARIANTS OF SHIGELLA SONNEI [PDF]

Journal of Experimental Medicine, 1949
It has been shown that phase variation of Sh. sonnei is accompanied by changes in morphology and antigenic structure. Two mutants of the Phase I organism (IIS and IIR), which were studied, elaborate somatic antigens which are immunologically identical.
Walther F Goebel, Goebel Walther F
exaly   +3 more sources

Cross-comparison study of three ELISA methodologies to measure Shigella Sonnei O-antigen serum IgG [PDF]

mSphere
Measurement of serum immunoglobulin G (IgG) to Shigella lipopolysaccharide (LPS) has been proposed as a correlate of protection against shigellosis, the confirmation of which in the target population of infants in low- and middle-income countries will ...
Paul Stickings, Caroline Vipond, Peter Rigsby, Francesca Micoli, Omar Rossi, Francesca Mancini, Valentino Conti, Dani Cohen, Anya Bialik, Shiri Meron-Sudai, Valeria Asato, Kristen A. Clarkson, Calman A. MacLennan, Robert W. Kaminski   +13 more
doaj   +2 more sources

Protein-specific immune response elicited by the Shigella sonnei 1790GAHB GMMA-based candidate vaccine in adults with varying exposure to Shigella [PDF]

mSphere
Shigella is a leading cause of diarrheal morbidity and mortality in young children from low- and middle-income countries. Here, we aimed to verify the ability of the generalized modules for membrane antigens (GMMA)-based Shigella sonnei candidate vaccine
Arlo Z. Randall, Valentino Conti, Usman Nakakana, Xiaowu Liang, Andy A. Teng, Antonio Lorenzo Di Pasquale, Melissa Kapulu, Robert Frenck, Odile Launay, Pietro Ferruzzi, Antonella Silvia Sciré, Elisa Marchetti, Christina Obiero, Jozelyn V. Pablo, Joshua Edgar, Philip Bejon, Adam D. Shandling, Joseph J. Campo, Angela Yee, Laura B. Martin, Audino Podda, Francesca Micoli   +21 more
doaj   +2 more sources

IgG Serum Antibodies to Shigella sonnei Lipopolysaccharide Are Inversely Associated with the Incidence of Culture-Proven S. sonnei Shigellosis in Israeli Children and Adolescents [PDF]

Vaccines
Background: Shigella is a leading cause of moderate-to-severe diarrhea globally, with young children most affected. The burden of shigellosis drops increasingly with age, inferring the acquisition of natural immunity.
Valeria Asato, Ravit Bassal, Shiri Meron-Sudai, Sophy Goren, Lital Keinan-Boker, Calman A. MacLennan, Dani Cohen   +6 more
doaj   +2 more sources