PLoS ONE, 2021 IntroductionShigellosis, is a leading cause of moderate-to-severe diarrhoea and related mortality in young children in low and middle income countries (LMICs).
Caroline C Chisenga +11 more
doaj +1 more source
Deletion of toxin–antitoxin systems in the evolution of Shigella sonnei as a host-adapted pathogen [PDF]
, 2016 Pathogenic Shigella spp. are the leading cause of bacterial dysentery, with Shigella flexneri and Shigella sonnei accounting for around 90% of cases worldwide. While S.
McVicker, G, Tang, CM
core +1 more source
Evaluation of a Live Attenuated S. sonnei Vaccine Strain in the Human Enteroid Model
Pathogens, 2021 Shigella is a leading cause of bacillary dysentery worldwide, responsible for high death rates especially among children under five in low–middle income countries.
Giulia Pilla +6 more
doaj +1 more source
Impact of insertion sequences on convergent evolution of Shigella species.
PLoS Genetics, 2020 Shigella species are specialised lineages of Escherichia coli that have converged to become human-adapted and cause dysentery by invading human gut epithelial cells.
Jane Hawkey +4 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg +21 more
wiley +2 more sources
The multivalent adhesion molecule SSO1327 plays a key role in Shigella sonnei pathogenesis : SSO1327 is an adhesin required for S. sonnei pathogenesis [PDF]
, 2015 Shigella sonnei is a bacterial pathogen and causative agent of bacillary dysentery. It deploys a type III secretion system to inject effector proteins into host epithelial cells and macrophages, an essential step for tissue invasion and immune evasion ...
Eldomany, R A +8 more
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Establishment of a Controlled Human Infection Model with a Lyophilized Strain of
mSphere, 2020 Controlled human infection models (CHIMs) are useful for vaccine development. To improve on existing models, we developed a CHIM using a lyophilized preparation of Shigella sonnei strain 53G produced using current good manufacturing practice (cGMP ...
Robert W. Frenck +14 more
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A Shigella sonnei Outbreak in Nagasaki
Journal of the Japanese Association for Infectious Diseases, 2000 We have experienced an outbreak of dysentery in Nagasaki. Shigella sonnei were positively cultured from 467 patients out of suspected 821 cases, and 346 patients were admitted. 121 patients were treated with oral antimicrobials in the outpatient clinic. Five patients were diagnosed as secondary infection.
A, Hamamoto +4 more
openaire +3 more sources
South Asia as a Reservoir for the Global Spread of Ciprofloxacin-Resistant Shigella sonnei: A Cross-Sectional Study. [PDF]
, 2016 BACKGROUND: Antimicrobial resistance is a major issue in the Shigellae, particularly as a specific multidrug-resistant (MDR) lineage of Shigella sonnei (lineage III) is becoming globally dominant.
Baker, Stephen +21 more
core +2 more sources
Trends in antimicrobial resistance in Shigella species in Karachi, Pakistan. [PDF]
, 2009 Background: Shigellosis is a common cause of morbidity, especially in the very young and old, in developing countries. The disease is treated with antibiotics.
Ejaz, Muslima +5 more
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