Results 41 to 50 of about 39,545 (207)
Finding potential drug targets against Shigella flexneri through druggable proteome exploration.
Frontiers in Microbiology, 2016 :Background: Shigella flexneri is a gram negative bacteria that causes the infectious disease ‘shigellosis’. Shigella flexneri (S. flexneri) is responsible for developing diarrhea, fever and stomach cramps in human.
Mohammad Uzzal Hossain +6 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.We demonstrate that bacterial outer membrane vesicles (OMVs) can enhance antibiotic delivery into Gram‐negative bacteria by bypassing porin‐dependent uptake. Encapsulation of imipenem in OMVs significantly increased its effectiveness against multidrug‐resistant clinical isolates, highlighting OMVs as a promising platform for overcoming permeability ...
Meishan Wu +3 more
wiley +1 more source
Expression of bacterial virulence factors and cytokines during in vitro macrophage infection by enteroinvasive Escherichia coli and Shigella flexneri: a comparative study [PDF]
, 2010 Enteroinvasive Escherichia coli (EIEC) and Shigellaspp cause bacillary dysentery in humans by invading and multiplying within epithelial cells of the colonic mucosa.
ALBUQUERQUE, José AT +5 more
core +3 more sources
Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application
Chemistry &Biodiversity, EarlyView.ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade +4 more
wiley +1 more source
Shigella OspC3 suppresses murine cytosolic LPS sensing
iScience, 2021 Summary: Shigella flexneri, a cytosol-invasive gram-negative pathogen, deploys an array of type III-secreted effector proteins to evade host cell defenses.
Changhoon Oh +4 more
doaj +1 more source
Small, EarlyView.Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Shigella flexneri serotype 1c derived from serotype 1a by acquisition of gtrIC gene cluster via a bacteriophage [PDF]
, 2016 BACKGROUND: Shigella spp. are the primary causative agents of bacillary dysentery. Since its emergence in the late 1980s, the S. flexneri serotype 1c remains poorly understood, particularly with regard to its
Cam, Phung D +4 more
core +1 more source
Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation
The FEBS Journal, EarlyView.This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley +1 more source
Microbiology SpectrumThe objective of this study was to assess the prevalence, antimicrobial resistance patterns, and risk factors linked to Shigella infections through a nationwide hospital-based diarrheal disease surveillance in Bangladesh.
Mokibul Hassan Afrad +12 more
doaj +1 more source
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 1, January 2026.ABSTRACT In the U.S., bovine milk is processed using thermal pasteurization to ensure microbial safety. However, this process alters the structure of heat‐sensitive bioactive proteins associated with the functional benefits of raw milk, including antimicrobial, immunomodulatory, and antioxidant proteins.
Rudy Sykora +5 more
wiley +1 more source