Results 41 to 50 of about 40,170 (206)

Clinical implications of reduced susceptibility to fluoroquinolones in paediatric Shigella sonnei and Shigella flexneri infections. [PDF]

, 2015
OBJECTIVES: We aimed to quantify the impact of fluoroquinolone resistance on the clinical outcome of paediatric shigellosis patients treated with fluoroquinolones in southern Vietnam.
Baker, Stephen, Campbell, James I, Chau, Nguyen Van Vinh, Duc, Anh Nguyen, Hoang, Nguyen Van Minh, Lan, Nguyen Phu Huong, Ngoc, Dung Tran Thi, Nguyen, To Nguyen Thi, Parry, Christopher M, Thanh, Duy Pham, Thanh, Tuyen Ha, The, Hao Chung, Thieu, Nga Tran Vu, Thompson, Corinne N, Thwaites, Guy, Vinh, Ha, Vinh, Phat Voong, Wolbers, Marcel   +17 more
core   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

LPS unmasking of Shigella flexneri reveals preferential localisation of tagged outer membrane protease IcsP to septa and new poles [PDF]

, 2013
The Shigella flexneri outer membrane (OM) protease IcsP (SopA) is a member of the enterobacterial Omptin family of proteases which cleaves the polarly localised OM protein IcsA that is essential for Shigella virulence.
A Kaufmann, A Typas, AJ Egan, AM Lynne, AS Ghosh, B Lugtenberg, C Egile, Daniela Flavia Hozbor, DL Voorhis, E LaBrec, Elizabeth Ngoc Hoa Tran, GL Murray, H d’Hauteville, I Fukuda, J Brosius, J Dworkin, J Lutkenhaus, J Steinhauer, JR Robbins, KA Datsenko, KA Gibbs, KD Shere, KL May, L Purins, L Van Den Bosch, L Vandeputte-Rutten, LM Guzman, M Papadopoulos, Matthew Thomas Doyle, MB Goldberg, MB Goldberg, MC Lett, MJ Osborn, MJ Osborn, ML Bernardini, MY Teh, P Van der Ley, P Van der Ley, PR Reeves, R Morona, R Morona, RC Sandlin, RE Rose, Renato Morona, RM Horton, S Chatterjee, S Jain, S Tamaki, T Suzuki, TE Fehniger, TS Ursell   +50 more
core   +3 more sources

Bordetella BcrH1 and BcrH2 Are Specific Chaperones for the Pore‐Forming Complex

Microbiology and Immunology, EarlyView.
ABSTRACT Bordetella has a type III secretion system that secretes virulence proteins crucial to the establishment of infection. The genes encoding components of the Bordetella type III secretion system are located in the bsc region on the chromosome. This region includes the bcrH1 and bcrH2 genes, which respectively encode the proteins BcrH1 and BcrH2.
Yuya Kishino, Toshinobu Ogawa, Hiroko Sato, Akio Abe, Asaomi Kuwae   +4 more
wiley   +1 more source

Shigella flexneri serotype 1c derived from serotype 1a by acquisition of gtrIC gene cluster via a bacteriophage [PDF]

, 2016
BACKGROUND: Shigella spp. are the primary causative agents of bacillary dysentery. Since its emergence in the late 1980s, the S. flexneri serotype 1c remains poorly understood, particularly with regard to its
Cam, Phung D, Carlin, Nils I A, Talukder, Kaisar A, Tang, Swee-Seong, Verma, Naresh K   +4 more
core   +1 more source

Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation

The FEBS Journal, EarlyView.
This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley   +1 more source

Shigella OspC3 suppresses murine cytosolic LPS sensing

iScience, 2021
Summary: Shigella flexneri, a cytosol-invasive gram-negative pathogen, deploys an array of type III-secreted effector proteins to evade host cell defenses.
Changhoon Oh, Ambika Verma, Mohib Hafeez, Brandon Hogland, Youssef Aachoui   +4 more
doaj   +1 more source

The FsrA‐Mediated Iron‐Sparing Response Regulates the Biosynthesis of the Epipeptide EPE in Bacillus subtilis

Molecular Microbiology, EarlyView.
Under iron‐limited conditions, FsrA base‐pairs with the intergenic region between epeX and epeE, enhancing epeE translation and triggering EPE production. Toxin‐mediated cell lysis releases nutrients, including iron, which can be taken up by surviving cells.
Sarah Miercke, Rabea Ghandour, Kai Papenfort, Thorsten Mascher   +3 more
wiley   +1 more source

Escherichia coli EHEC Germany outbreak preliminary functional annotation using BG7 system [PDF]

, 2011
We have annotated the European outbreak E. coli EHEC genome sequenced by BGI (6-2-2011) and assembled with MIRA by Nick Loman (6-2-2011 ). Our system BG7, Bacterial Genome annotation of Era7 Bioinformatics, predicts ORFs and annotates them based on ...
Eduardo Pareja, Eduardo Pareja-Tobes, Marina Manrique, Pablo Pareja-Tobes, Raquel Tobes   +4 more
core   +2 more sources

Vaccine Candidates Designed to Prevent Enterotoxigenic Escherichia coli Diarrhoea: A Scoping Review of Clinical Trials Evaluating Vaccine Candidates in Development

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objectives The primary objectives of this study are to (1) summarise the current landscape of ETEC vaccine development by describing, characterising and comparing ETEC vaccine candidates in clinical development, (2) assess key characteristics of the phases 1, 2 and 3 clinical trials that have been designed to evaluate ETEC vaccines in ...
Vaidehi Nafade, Naheemot O. Sule, Yang Zhang, Angelina Sassi, Nicole E. Basta   +4 more
wiley   +1 more source