Results 191 to 200 of about 985,996 (219)

In-silico Evaluation of Five Antituberculosis Drug Candidates Targeting Shikimate Kinase of Mycobacterium tuberculosis

Biointerface Research in Applied Chemistry
The shikimate pathway is considered a promising target for the development of new anti-tuberculosis drugs (ATD) due to its vital role in the survival of Mycobacterium tuberculosis and its absence in mammals, which minimizes the risk of toxicity.
N. B. Nugroho, Fahmi Nurhidayat, Annisa Annisa   +2 more
semanticscholar   +1 more source

An integrated computational hierarchy for identification of potent inhibitors against Shikimate Kinase enzyme from Shigella sonnei , a major cause of global dysentery

Gene Reports, 2018
Shikimate Kinase is an enzyme of shikimate pathway, characterized as non-paralog, non-homolog, and essential for bacterial survival. Shikimate Kinase enzyme assists in catalysis of the ATP-dependent phosphorylation of shikimate to produce shikimate 3 ...
Sajjad Ahmad, Shehneela Baseer, Afifa Navid, Faisal Ahmad, S. S. Azam   +4 more
semanticscholar   +1 more source

Effects of salts on the function and conformational stability of shikimate kinase

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
The unfolding of shikimate kinase (SK) from Erwinia chrysanthemi by urea and its subsequent refolding on dilution of the denaturing agent has been studied in detail [Eur. J. Biochem. 269 (2002) 2124]. Comparison of the effects of urea on the enzyme with those of guanidinium chloride (GdmCl) and NaCl indicated that chloride ions significantly weakened ...
Eleonora, Cerasoli, Sharon M, Kelly, John R, Coggins, Adrian J, Lapthorn, David T, Clarke, Nicholas C, Price   +5 more
openaire   +2 more sources

The gene (aroK) encoding shikimate kinase I fromEscherichia coli.

DNA Sequence, 1995
Shikimate kinase I (SKI), encoded by the aroK gene, converts shikimate to shikimate 3-phosphate, an intermediate in the biosynthesis of the aromatic amino acids. This paper provides evidence that the E. coli aroK reading frame is in a different place to that reported previously and presents a predicted SKI sequence of 173 residues and a molecular mass ...
H G, Griffin, M J, Gasson
openaire   +2 more sources

Mechanistic studies on chorismate synthase and shikimate kinase

2018
This thesis was digitised by the British Library from microfilm. You can acquire a single copy of this thesis for research purposes by clicking on the padlock icon on the thesis file. Please be aware that the text in the supplied thesis pdf file may not be as clear as text in a thesis that was born digital or digitised directly from paper due to the ...
openaire   +1 more source

Shikimate kinase

1997
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Pharmacophore-based virtual screening and molecular docking of secondary metabolites of Aspergillus spp. to identify Mycobacterium tuberculosis shikimate kinase inhibitor

AIP Conference Proceedings
Titin Ariyani, Mohamad Sadikin, E. Prabandari   +2 more
semanticscholar   +1 more source

Identification of potential inhibitors of shikimate kinase from Mycobacterium tuberculosis using in silico approach

Journal of Proteins and Proteomics
M. A. Isa, M. M. Mohammed, Muhammad Musa Ibrahim, F. Gubio, F. Buba, Somia Shehzadi   +5 more
semanticscholar   +1 more source

Finding the First Potential Inhibitors of Shikimate Kinase from Methicillin Resistant Staphylococcus aureus through Computer-Assisted Drug Design

Molecules, 2021
Alfredo Téllez-Valencia, Erick Sierra-Campos, Marcelo Gómez Palacio- Gastelum   +2 more
exaly  

The three-dimensional structure of shikimate kinase 1 1Edited by K. Nagai

Journal of Molecular Biology, 1998
Tino Krell
exaly