Results 171 to 180 of about 985,996 (219)

Discovery of Helicobacter pylori shikimate kinase inhibitors: Bioassay and molecular modeling

Bioorganic and Medicinal Chemistry, 2007
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway and catalyzes the phosphate transfer from ATP to shikimate in generating shikimate 3-phosphate and ADP. SK has been developed as a promising target for the discovery of antibacterial agents.
Jian Zhang, Xu Shen, Jiang Hualiang
exaly   +3 more sources

Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase

Biochemical and Biophysical Research Communications, 2016
The molecular bases of disease provide exceptional prospect to translate research findings into new drugs. Nevertheless, to develop new and novel chemical entities takes huge amount of time and efforts, mainly due to the stringent processes. Therefore, drug repurposing is one of such strategies which is being used in recent times to identify new ...
Aditi Chatterjee, Swati Jaiswal, Sanjay Kumar   +2 more
exaly   +3 more sources

Identification of novel antimicrobial compounds targeting Mycobacterium tuberculosis shikimate kinase using in silico hierarchical structure-based drug screening.

Tuberculosis, 2023
The development of new anti-TB drugs to prevent the spread of multidrug-resistant Mycobacterium tuberculosis (Mtb) strains is imperative. Mtb shikimate kinase (MtSK) was selected as the target protein to screen for new anti-TB drugs.
S. Kawamoto, Chihiro Hori, Hinata Taniguchi, Saya Okubo, Shunsuke Aoki   +4 more
semanticscholar   +1 more source

Understanding the Catalytic Mechanism and the Nature of the Transition State of an Attractive Drug-Target Enzyme (Shikimate Kinase) by Quantum Mechanical/Molecular Mechanical (QM/MM) Studies.

Chemistry - A European Journal, 2017
Jianzhuang Yao, Xia Wang, Haixia Luo, P. Gu   +3 more
semanticscholar   +3 more sources

Synthesis, molecular docking, and biological evaluation of novel 1,2,4‐triazole‐isatin derivatives as potential Mycobacterium tuberculosis shikimate kinase inhibitors

Chemical Biology and Drug Design, 2022
The issue of emerging resistance to antitubercular drugs has created a formidable barrier in the effective prevention and cure of tuberculosis globally. In an effort to search for new antimycobacterial agents, possibly comprising new pharmacophore, novel
Vedika Dadlani, Heta Chhabhaiya, R. Somani, P. Tripathi   +3 more
semanticscholar   +1 more source

Design, Synthesis and Antitubercular Study of Novel Pyrazoline Moiety as Mycobacterium Tuberculosis shikimate kinase inhibitor

Research Journal of Pharmacy and Technology, 2022
A series of pyrazoline comprising coumarin moiety was docked against Mycobacterium tuberculosis shikimate kinase which is an essential target for novel anti tubercular drug design.
D. P, D. D. Maheshwari, M. Kumar, B. Venkateswarlu, Vimal. K. R   +4 more
semanticscholar   +1 more source

Tuberculosis shikimate kinase as a target for the development of new antimycobacterials

The FASEB Journal, 2021
Tuberculosis is a respiratory infection with over 10 million reported cases each year. This infection rate is responsible for over two million deaths annually, second only to HIV in fatalities among infectious diseases. Since 1960 tuberculosis rates have
Marcin Ogrodniczuk, René Fuanta
semanticscholar   +1 more source

Screening of antitubercular compound library identifies novel shikimate kinase inhibitors of Mycobacterium tuberculosis

Applied Microbiology and Biotechnology, 2016
V. Rajput, Rukmankesh Mehra, Sanjay Kumar, A. Nargotra, P. Singh, I. Khan   +5 more
semanticscholar   +3 more sources

Molecular model of shikimate kinase from Mycobacterium tuberculosis

Biochemical and Biophysical Research Communications, 2002
Tuberculosis (TB) resurged in the late 1980s and now kills approximately 3 million people a year. The reemergence of tuberculosis as a public health threat has created a need to develop new anti-mycobacterial agents. The shikimate pathway is an attractive target for herbicides and anti-microbial agents development because it is essential in algae ...
De Azevedo Jr., Walter Filgueira, Canduri, Fernanda, De Oliveira, Jaim Simões, Basso, Luiz Augusto, Palma, Mario Sergio, Pereihenrra, José Henrique, Santos, Diógenes Santiago   +6 more
openaire   +3 more sources

Shikimate Kinase, a Protein Target for Drug Design

Current Medicinal Chemistry, 2014
ATP: shikimate 3-phosphotransferase catalyzes the fifth chemical reaction of shikimate pathway. This metabolic route is responsible for the production of chorismate, a precursor of aromatic amino acids. This especially interesting enzymatic step is indispensable for the survival of the etiological agent of tuberculosis and not found in animals ...
J D, Coracini, W F, de Azevedo
openaire   +2 more sources