Results 41 to 50 of about 785,642 (238)

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

A Scalable Droplet Microfluidic Platform That Overcomes Large‐Cell Constraints for Long‐Term Plant Cell Culture and Embryogenesis Analysis

Advanced Science, EarlyView.
This work presents a large‐cell‐compatible droplet microfluidic platform that overcomes long‐standing barriers in plant cell culture by enabling high‐fidelity encapsulation, novel multilayer 3D droplet incubation for scalable long‐term culture, and support for the full developmental progression of large plant cells.
Arman Mirmiran, Fangchi Shao, Gregory Datto, Tathansh Joshi, Elizabeth Chatt, Yashar Bashirzadeh, Dan Stessman, Lai Wei, Kuangwen Hsieh, Hena Guo, Tza‐Huei Wang   +10 more
wiley   +1 more source

Ship Trajectory Classification Prediction at Waterway Confluences: An Improved KNN Approach

Journal of Marine Science and Engineering
This study presents a method to support ship trajectory prediction at waterway confluences using historical Automatic Identification System (AIS) data.
Zhiyuan Wang, Wei He, Jiafen Lan, Chuanguang Zhu, Jinyu Lei, Xinglong Liu   +5 more
doaj   +1 more source

Long‐Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

Advanced Science, EarlyView.
An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma, Evelien Schaafsma, Elysia Anderson, Jocelyn Chiari, Paige Thompson, Erin Galt, Sunghoon Lee, Jason Holsapple, Sai Hein, Bailey L. Coates, Jade Michaud, Sabrina Zuccaro, Lia Kent, Chris Hinojosa, Kyung‐Jin Jang   +14 more
wiley   +1 more source

MPF2010: The Maritime Preposition Ship Force 2010

, 1998
Web page capture of TSSE Team 1998 - MPF2010: The Maritime Preposition Ship Force 2010 project page, as it appeared July 2, 2025.A systems engineering approach to the design of a ship which will satisfy the requirements for a Maritime Prepositioning ...

core   +1 more source

Ship Trajectory Prediction in Complex Waterways Based on Transformer and Social Variational Autoencoder (SocialVAE)

Journal of Marine Science and Engineering
Ship trajectory prediction plays a key role in the early warning and safety of maritime traffic. It is a necessary assistant tool that can forecast a ship’s trajectory in a certain period to prevent ship collision.
Pengyue Wang, Mingyang Pan, Zongying Liu, Shaoxi Li, Yuanlong Chen, Yang Wei   +5 more
doaj   +1 more source

Optimization of LSTM Ship Trajectory Prediction Based on Hybrid Genetic Algorithm [PDF]

Journal of Geodesy and Geoinformation Science
Accurate prediction of the movement trajectory of sea surface targets holds significant importance in achieving an advantageous position in the sea battle field.
ZHAO Pengfei
doaj   +1 more source

An Improved Ship Trajectory Prediction Based on AIS Data Using MHA-BiGRU

Journal of Marine Science and Engineering, 2022
According to the statistics of water transportation accidents, collision accidents are on the rise as the shipping industry has expanded by leaps and bounds, and the water transportation environment has become more complex, which can result in grave ...
Kexin Bao, Jinqiang Bi, Miao Gao, Yue Sun, Xuefeng Zhang, Wenjia Zhang   +5 more
doaj   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

The Maritime Preposition Force Ship 2010 [PDF]

, 1999
Part of TSSE Team 1998 - MPF2010: The Maritime Preposition Ship Force 2010 projectThe views expressed in this report are those of the authors and do not reflect the offical policy or position of the Department of Defense or the U.S.
Weekly, Randolph R., Harney, Robert C., Kan, Joseph, Vaidyanathan, Rajan, Calvano, Charles N., Anderson, Thomas, McKerrow, Gary, Arrington, Jess   +7 more
core   +2 more sources