Vitamin B12 combined with methylene blue alleviates experimental septic shock and is associated with modulation of KCNMB1 and the cGMP-PRKG pathway. [PDF]
PLoS OneShan K, Zhao J, Tang K, Lei Y, Mao F.
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Enhancing Adeno‐Associated Virus 2 Capsid Engineering Through Co‐Evolutionary Coupling
Biotechnology and Bioengineering, EarlyView.ABSTRACT Adeno‐associated virus (AAV) has emerged as a leading platform for gene therapy. However, to unlock the full potential, their manufacturing yields, stability, and efficacy must all be improved. Rational design is limited by poor predictability and the potential impact of mutations on multiple important vector properties.
Sirimar Laosinwattana +4 more
wiley +1 more source
Validation of the updated sequential organ failure assessment (SOFA)-2 score in emergency department septic shock. [PDF]
J Intensive CareAhn S +8 more
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Prioritized factors of severity prognosis in patients admitted for sepsis or septic shock in a resource-limited region of central Vietnam. [PDF]
J Crit Care Med (Targu Mures)Xuan TT +7 more
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Hexosylceramide Species in the Blood Decline in Both COVID-19 and Non-COVID-19 Sepsis. [PDF]
BiomedicinesPavel V +7 more
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Role of bacterial pathogens and toxins in sepsis-related myocardial injury: a scoping review. [PDF]
BMJ OpenLörstad S +4 more
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Systems Bioengineering of Septic Shock Metabolism: Citrulline, β-Hydroxybutyrate and Plasma Biomarker-Based Phenotyping. [PDF]
BiomoleculesAzamfirei L +4 more
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1. Septic shock is still a major complication of patients in intensive care units (ICUs) and, therefore, a main goal of ICU-related research. 2. After the unsatisfying results of multicenter clinical trials in blocking proinflammatory mediators such as tumor necrosis factor and interleukin-1 or endotoxin itself, research has focused on other important ...
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Septic shock, the most severe complication of sepsis, is a deadly disease. In recent years, exciting advances have been made in the understanding of its pathophysiology and treatment. Pathogens, via their microbial-associated molecular patterns, trigger sequential intracellular events in immune cells, epithelium, endothelium, and the neuroendocrine ...
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