Results 131 to 140 of about 2,200,311 (344)

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Computational Investigations and Control of Shock Interference

Applied Sciences
Computational fluid dynamics (CFD) has aided the development, design, and analysis of hypersonic airbreathing propulsion technologies, such as scramjets. The complex flow field in a scramjet isolator has been the subject of intense interest and study for
Cameron Alexander, Ragini Acharya
doaj   +1 more source

Kinetic theory and turbulent discontinuities [PDF]

Shock tube discontinuities were used to test and extend a kinetic theory of turbulence. In shock wave and contact surface fluctuations, coherent phenomena were found which provide new support for the microscopic nonempirical approach to turbulent systems,
I, L., Johnson, J. A., III, Li, Y., Ramaian, R., Santigo, J. P.   +4 more
core   +1 more source

Geometric theory of flexible and expandable tubes conveying fluid: equations, solutions and shock waves

, 2018
We present a theory for the three-dimensional evolution of tubes with expandable walls conveying fluid. Our theory can accommodate arbitrary deformations of the tube, arbitrary elasticity of the walls, and both compressible and incompressible flows ...
Gay-Balmaz, François, Putkaradze, Vakhtang   +1 more
core   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Investigating the use of low and high-density polyethylene blends with waste material from three-layer factory tube for the third layer of shock tubes

Frontiers in Chemistry
Polymeric shock tubes are now widely used in explosives systems for drilling and mining operations. Most shock tubes on the market consist of three layers of polymer, the first layer being Surlyn 8940 copolymer, the second layer Nucrel 31001 and the ...
Ali Khalili Gashtroudkhani, Mohammad Dahmardeh Ghaleno, Saeed Soltan Abadi, Maryam Pouyani   +3 more
doaj   +1 more source

The autoignition of cyclopentane and cyclohexane in a shock tube

, 2007
Ignition delay times of cyclohexane-oxygen-argon and cyclopentane-oxygen-argon mixtures have been measured in a shock tube, the onset of ignition being detected by OH radical emission. Mixtures contained 0.5 or 1 % of hydrocarbon for equivalence ratios ranging from 0.5 to 2.
Sirjean, Baptiste, Buda, Frédéric, Hakka, Hichem, Glaude, Pierre-Alexandre, Fournet, René, Warth, Valérie, Battin-Leclerc, Frédérique   +6 more
openaire   +3 more sources

Plasma conductivity gage [PDF]

, 1970
Gage permits determination of stagnation conductivity from measurement of shunt impedance presented by the plasma between the inner and outer conductors of a segment of coaxial transmission line.
Gill, S. P.
core   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source