Results 171 to 180 of about 522,480 (206)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

A Semi‐Analytical Energy Model for Particle‐Based Fluid Simulation Involving Complex Moving Boundaries

Computer Graphics Forum, EarlyView.
Abstract While semi‐analytical boundary handling techniques have proven effective for modeling particle‐based fluid‐solid interactions, they can become unstable when applied to mesh boundaries undergoing dynamic motion or featuring complex, sharp geometries.
Junyuan Liu, Shusen Liu, Yuzhong Guo, Ruikai Liang, Ying Li, Xiaowei He   +5 more
wiley   +1 more source

SlideSAVR: Enabling Live Analysis during Data Presentations via Multimodal Sketching and Voice Input

Computer Graphics Forum, EarlyView.
Abstract Interpersonal communication in data science can yield sought‐after insights, but presentation environments are often not conducive for live analysis, forcing the process to move offline. Through a formative survey with 16 participants, we identified both technical (e.g., complexity of tools) and psychological (e.g., pressure of programming ...
C. Han, M.M. Tanjim, S. Guo, C. Dierk, K.E. Isaacs, J. Hoffswell   +5 more
wiley   +1 more source

Risking Response‐Ability

Educational Theory, EarlyView.
Abstract “Risking response‐ability” names the risky pedagogical work of being addressed by humans and more‐than‐human others alike, and of finding ourselves called to respond. In this article, I bring Gert Biesta's account of “pedagogical risk” into conversation with Donna Haraway's notion of “response‐ability,” arguing that education's force lies in ...
Jessica Lussier
wiley   +1 more source

Comminuted fractures of the proximal phalanx in horses: A multicentre retrospective review

Equine Veterinary Education, EarlyView.
Summary Background Comminuted fractures of the proximal phalanx (CFPP), defined as the presence of three or more major fracture fragments, present difficult management challenges. Feedback from practitioners and long‐term follow‐up can be helpful to reassess evidence‐based treatment strategies and improve clinical outcomes.
C. de Chaisemartin, M. Farfan, B. Dal Cero, A. Martens, F. Rossignol, A. Kalinovskiy, C. Lischer, C. Tessier, S. Grulke, G. Manneveau, V. Gouzer, G. Gomez, J. Samsel, C. Mespoulhes‐Riviere, F. Pichereau, L. Alfonso Gracia Calvo, M. Trécu, A. Spadaro Rossello, P. Planes, X. Peyrecave, C. Mansuy, C. Henry‐Perin, A. Guezennec, M. C. Schramme   +23 more
wiley   +1 more source

Reactive oxygen species, antioxidants and the regulation of plant development

The FEBS Journal, EarlyView.
The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi, Christine H. Foyer, Michael J. Considine   +2 more
wiley   +1 more source

T2T genome assembly and CRISPR/Cas9 editing of Medicago lupulina

Journal of Integrative Plant Biology, EarlyView.
A complete, gap‐free genome of Medicago lupulina, a tough, high‐protein forage legume, and a gene‐editing tool for this species, which was used to alter its leaf shape, provide key resources for improving alfalfa and breeding better forage crops for high‐altitude environments.
Qing Yuan, Cheng Li, Guangyan Wang, Wenfei Dai, Eerdungaridi, Di Wu, Qingdun Fan, Yongping Yang, Yuanwen Duan, Xudong Sun   +9 more
wiley   +1 more source

S‑glutathionylation of MaWRKY44 orchestrates a MaZFP139‐MaWRKY44‐MaGSTU07 cascade to enhance banana cold tolerance

Journal of Integrative Plant Biology, EarlyView.
In banana, at low temperatures (7°C), the transcription factor MaZFP139 activates MaWRKY44 expression. MaWRKY44 binds to the W‐box sites in the promoter of the glutathione S‐transferase gene MaGSTU07 to enhance reactive oxygen species scavenging. S‐glutathionylation protects MaWRKY44 from oxidation‐induced degradation, reinforcing antioxidant defenses ...
Shuqin Lin, Wen Song, Shaoting Liao, Haike Tan, Jianji Qi, Danling Cai, Wei Wei, Wei Shan, Jianfei Kuang, Jianye Chen, Wangjin Lu   +10 more
wiley   +1 more source

Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death

Journal of Periodontal Research, EarlyView.
Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee, Eun‐Nam Kim, Gil‐Saeng Jeong   +2 more
wiley   +1 more source