Results 221 to 230 of about 63,521 (300)

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi   +19 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye   +5 more
wiley   +1 more source

Identifying Failure Predictors in Thyroid Nodule Radiofrequency Ablation Using Multivariate Analysis: A Single‐Centre Experience

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Background Radiofrequency ablation (RFA) has become an established minimally invasive treatment for benign thyroid nodules (BTN), offering excellent safety and efficacy. However, factors predicting treatment success and post‐procedural thyroid dysfunction remain incompletely understood.
Shmuel Wechsler   +3 more
wiley   +1 more source

Nanosilicates Enhanced Periodontal Angiogenesis by Regulating Microtubule Dynamic‐Mediated STAT3 Pathway

open access: yesCell Proliferation, EarlyView.
Nanosilicates triggered MAP4‐dependent microtubule remodelling via the ROS/MAPK pathway, shifting microtubules into a dynamic active state, which subsequently promoted activation of the STAT3 pathway, ultimately facilitating periodontal angiogenesis.
Lingling Shang, Yuhan Hu, Shaohua Ge
wiley   +1 more source

Economic benefits of biodiversity corridors: A cross‐sectional study of households in the Central Annamite Landscape, Vietnam

open access: yesConservation Science and Practice, EarlyView.
Abstract Biodiversity corridors aim to reconnect fragmented habitats and protected areas, yet their impact on landowners varies and requires assessment. In the Central Annamite Landscape, Vietnam, initiatives like Payment for Forest Environment Services (PFES) for watershed protection, forest restoration, and non‐timber forest product development ...
Van Tri Tin Nguyen   +4 more
wiley   +1 more source

A Portable Multi‐Parameter Fluid Monitoring Unit for Real‐Time Measurements During Well Development and Geothermal Operations

open access: yesGroundwater Monitoring &Remediation, EarlyView.
Abstract Monitoring of fluid parameters during well development, groundwater production, or geothermal operation is essential for the understanding of subsurface and well processes. We developed FluMoMax, a portable fluid monitoring unit, that can measure several physicochemical parameters in real‐time, to monitor fluid characteristics and to enable ...
Lioba Virchow   +5 more
wiley   +1 more source

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