Results 71 to 80 of about 97,868 (303)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Generalized Enhanced PWM for Multilevel Current Source Inverters

IEEE Access
In power electronic converter topologies, when voltage and current stresses on power devices differ while operating at the same switching frequency and enduring these stresses for equal durations, power losses cannot be evenly distributed.
Faramarz Faraji, Honnyong Cha
doaj   +1 more source

Pruning and integrated nutrient management for growth and yield of guava (Psidium guajava)

The Indian Journal of Agricultural Sciences, 2019
An experiment was conducted to study the effect of different combinations of pruning and plant nutrition on growth and yield of guava (Psidium guajava L.) during 2015–16 and 2016–17.
DALIT KUMAR JAYSWAL, D P SHARMA, A K DWEVEDI, T R SHARMA   +3 more
doaj   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

Far-red Light Detection in the Shoot Regulates Lateral Root Development through the HY5 Transcription Factor [PDF]

, 2018
Plants in dense vegetation compete for resources and detect competitors through reflection of far-red (FR) light from surrounding plants. This reflection causes a reduced red (R):FR ratio, which is sensed through phytochromes.
Kang, Chia-Kai, Keuskamp, Diederik H, Hayes, Scott, Plant Ecophysiology, van Gelderen, Kasper, Pierik, Ronald, Sub Plant Ecophysiology, Paalman, Richard   +7 more
core   +2 more sources

Effect of shoot topping intensity on 'Cabernet Franc' grapevine maturity in high-altitude region [PDF]

Pesquisa Agropecuária Brasileira, 2017
: The objective of this work was to evaluate the chemical composition of 'Cabernet Franc' grape subjected to different levels of shoot topping. The experiment was conducted in the 2008 and 2009 vintages, and the levels of shoot topping consisted of ...
Douglas André Würz, José Luiz Marcon Filho, Alberto Fontanella Brighenti, Ricardo Allebrandt, Betina Pereira de Bem, Maicon Magro, Leo Rufato, Aike Anneliese Kretzschmar   +7 more
doaj   +1 more source

Shooting through time: new insights from transcriptomic data

Trends in Plant Science, 2015
Plant evo-devo research aims to identify the nature of genetic change underpinning the evolution of diverse plant forms. A transcriptomic study comparing gene expression profiles in the meristematic shoot tips of three distantly related vascular plants suggests that different genes were recruited to regulate similar meristematic processes during ...
openaire   +5 more sources

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

A Series of New Control Methods for Single-Phase Z-Source Inverters and the Optimized Operation

IEEE Access, 2019
This paper proposes a series of new control methods for single-phase Z-source inverters. A detailed description of the concept and principle of each method is first presented, then a comparison among them is conducted comprehensively.
Wenzheng Xu, Ming Liu, Junwei Liu, Ka Wing Chan, Ka Wai Eric Cheng   +4 more
doaj   +1 more source