Results 101 to 110 of about 411,065 (301)

Spike: AI scheduling for Hubble Space Telescope after 18 months of orbital operations [PDF]

open access: yes
This paper is a progress report on the Spike scheduling system, developed by the Space Telescope Science Institute for long-term scheduling of Hubble Space Telescope (HST) observations.
Johnston, Mark D.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Improved Short-Term Batch Scheduling Flexibility Using Variable Recipes

open access: yesIndustrial & Engineering Chemistry Research, 2011
Batch scheduling and control decision levels are usually optimized separately, even though integrated decisions would potentially increase the overall performance of the plant. This work aims at including in the scheduling problem the operating conditions related to the control function, which are traditionally optimized and fixed beforehand, to shed ...
Capón García, Elisabet   +2 more
openaire   +3 more sources

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

A Study on Integration of Interdivisional Scheduling in Dynamically Changing Manufacturing Environment

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
In dynamically changing manufacturing environment, it is quite difficult to optimize interdivisional scheduling which reduces total manufacturing cost of all divisions in a factory following fluctuations in demand.
Yoshihiro YAO   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Suggestions to Improve Lean Construction Planning [PDF]

open access: yes, 2015
The Last Planner System® has been one of the most popular lean construction tools that offers a solution to tackle the problems of production management on construction sites.
Dave, Bhargav   +4 more
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Job order assignment at optimal costs in railway maintenance [PDF]

open access: yes, 2013
Tamping is an important part of railway maintenance. Well tamped ballast reduces track irregularities and increases travel safety and comfort. But if the ballast is in a bad condition, the train speed must be restricted, which leads to delays and penalty
Baldi, Mauro Maria   +3 more
core  

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