Results 51 to 60 of about 4,085,017 (238)

Data-Driven Bias Correction and Defect Diagnosis Model for In-Service Vehicle Acceleration Measurements

open access: yesSensors, 2020
Track quality instruments use low-cost accelerometers placed on or attached to the floors of operating trains, and these instruments collect substantial amounts of data over short inspection periods.
Lei Bai, Rengkui Liu, Qing Li
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Risk factor analysis for fast track protocol failure [PDF]

open access: yes, 2013
Background: The introduction of fast-track treatment procedures following cardiac surgery has significantly shortened hospitalisation times in intensive care units (ICU).
Arndt H Kiessling   +11 more
core   +2 more sources

Dynamic response of vehicle-track coupling system with an insulated rail joint [PDF]

open access: yes, 2013
The dynamic behavior of vehicle and track systems is studied in the presence of an insulated rail joint through a two-dimensional vehicle-track coupling model.
Grossoni, Ilaria   +3 more
core   +3 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

First Results Of TanDEM-X Along-Track Interferometry [PDF]

open access: yes, 2012
The interferometric imaging modes of the TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurements) satellite formation offer improved along-track interferometric capabilities e.g. through longer and multiple baselines.
Hartmut Runge   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Track association performance of the best hypotheses search method [PDF]

open access: yes, 2013
Uncontrolled space objects in the geostationary orbit domain are hazardous threats for active satellites. Catalogs need to be build up, in order to protect this precious domain. The Swiss ZimSMART telescope, located in Zimmerwald, regularly scans the
Fiedler, H.   +5 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

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