Results 61 to 70 of about 334,674 (285)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Women in the 2006 Olympic and Paralympic Winter Games: An Analysis of Participation, Leadership and Media Coverage [PDF]

, 2006
Increasing women's participation in the Olympic Movement as participants and leaders has been a slow and challenging process. While the number of "events" open to female athletes has increased steadily during the past 30 years, the actual number of ...
Donna A. Lopiano, Lisa Zurn, Marjorie A. Snyder   +2 more
core  

Tagging single muons and other long-flying relativistic charged particles by ultra-fast timing in air Cherenkov telescopes [PDF]

, 2006
Atmospheric air Cherenkov telescopes are successfully used for ground-based, very high-energy (VHE) gamma ray astronomy. Triggers from the so-called single muon and other long-flying relativistic charged particle events are an unwanted background for the
Bartko, Cabot, Chitnis, D. Sobczynska, E. Lorenz, M. Teshima, R. Mirzoyan, Vacanti, Weekes   +8 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Women in the 2010 Olympic and Paralympic Games: An Analysis of Participation, Leadership, and Media Opportunities [PDF]

, 2010
This report is the third in the series that follows the progress of women in the Olympic and Paralympic movement. The report provides the most accurate, comprehensive, and up-to-date examination of the participation trends among female Olympic and ...
Alison Wrynn, Maureen Smith
core  

Tracking Performance of the Scintillating Fiber Detector in the K2K Experiment

, 2002
The K2K long-baseline neutrino oscillation experiment uses a Scintillating Fiber Detector (SciFi) to reconstruct charged particles produced in neutrino interactions in the near detector.
A. Suzuki, Adams, Ahn, Ambrogiani, Annis, Ansorge, B.J. Kim, Billoir, C.K. Jung, C.W. Walter, E. Kearns, E. Sharkey, E.J. Jeon, Fruhwirth, Fukuda, G. Kume, H. Ishino, H. Park, H. Yokoyama, H.C. Bhang, H.G. Berns, H.I. Kim, Harr, Innocente, Ishii, J. Hill, J. Wilkes, J. Yoo, J.H. Kim, J.L. Stone, J.Y. Kim, K. Fujii, K. Nakamura, K. Nishikawa, K. Sato, K. Scholberg, K. Takenaka, Kalman, Kalman, M. Nakamura, M. Onchi, M. Sakuda, M. Takatsuki, M. Yoshida, N. Tamura, Nakahata, S. Aoki, S. Boyd, S. Matsuno, S. Mine, S.B. Kim, Suzuki, T. Hara, T. Ishida, T. Ishii, T. Iwashita, T. Kobayashi, T. Otaki, Wolin, Y. Hayato, Y. Oyama, Y. Tanaka   +61 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Data-Driven Bias Correction and Defect Diagnosis Model for In-Service Vehicle Acceleration Measurements

Sensors, 2020
Track quality instruments use low-cost accelerometers placed on or attached to the floors of operating trains, and these instruments collect substantial amounts of data over short inspection periods.
Lei Bai, Rengkui Liu, Qing Li
doaj   +1 more source

Is it possible to establish reference values for ankle muscle isokinetic strength? A meta-analytical study [PDF]

, 2014
BACKGROUND: The importance of measuring ankle muscle strength (AMS) has been demonstrated in a variety of clinical areas. Much data has been accumulated using the Cybex Norm isokinetic dynamometer but a uniform framework does not exist.
Fish, M, Killey, J, Milligan, J
core   +1 more source