Results 241 to 250 of about 96,244 (292)

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

open access: yesAdvanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija   +22 more
wiley   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li   +11 more
wiley   +1 more source

Short Cervix in a Patient With Twin Gestation

Obstetrics & Gynecology, 2017
A 28-year-old woman, gravida 1 para 0, with twin gestation presents for routine anatomic survey at 20 weeks of gestation without any complaints. On transabdominal ultrasonography, the ultrasonographer notes concern for cervical funneling and proceeds to perform a transvaginal ultrasonogram, which reveals a short cervix of 18 mm.
Manisha, Gandhi, Nathan S, Fox
openaire   +4 more sources

Management of Short Cervix during Pregnancy: A Review

American Journal of Perinatology, 2016
Sonographic evaluation of the uterine cervix has evolved as one of the best clinical tools available for the prediction of subsequent spontaneous preterm birth (PTB), particularly when combined with prior poor obstetric history. There is a growing body of evidence describing interventions for short cervix that reduce the risk of preterm delivery and ...
Jennifer, Gilner, Joseph, Biggio
openaire   +2 more sources

Short cervix: is a follow‐up measurement useful?

Ultrasound in Obstetrics & Gynecology, 2006
AbstractObjectiveTo study if a repeat cervical length (CL) measurement in the patient already diagnosed with a short cervix has any additional value in the prediction of preterm delivery.Study designThis was a retrospective study of singleton pregnancies with cervical lengths 1–25 mm at a gestational age of 16–28 weeks seen in our institution between ...
N S, Fox   +3 more
openaire   +2 more sources

Clinical Management of the Short Cervix

Obstetrics and Gynecology Clinics of North America, 2011
Cervical cerclage is associated with prolongation of gestation in singleton pregnancies with prior spontaneous preterm delivery and a short cervix on vaginal ultrasonography in the mid-trimester. Ultrasound screening of cervical length is not indicated in low-risk singleton pregnancies and in women with multiple gestations. 17α-Hydroxyprogesterone does
openaire   +2 more sources

Alternative Treatment for a Short Cervix: The Cervical Pessary

Seminars in Perinatology, 2009
Preterm birth is the leading cause of perinatal morbidity and mortality in the United States. The risk of preterm birth is inversely proportional to the length of the cervix on transvaginal sonography. The traditional treatment for a short cervix has been cerclage and recently there are newer trials using progesterone for this same indication.
Vanita B, Dharan, Jack, Ludmir
openaire   +2 more sources

Mid-trimester uterine electromyography in patients with a short cervix

American Journal of Obstetrics and Gynecology, 2022
Preterm birth is the largest single cause of infant death in the United States. A cervical length of
Ponnila S. Marinescu   +5 more
openaire   +2 more sources

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