Results 41 to 50 of about 96,244 (292)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Morphological and Molecular Identification of Limnodrilus Claparede,1862 Species(clitellata: naiDIDAE) IN Tigris River, Baghdad/Iraq

مجلة بغداد للعلوم, 2021
Sludge worm samples were collected from the Tigers River sediment during the period from November 2018 to June 2019 in Al Sarafiya District/ Baghdad- Iraq.
E. O. Zaar, H. J. Jaweir
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Longitudinal determination of serum placental protein 13 during development of preeclampsia [PDF]

, 2008
Objective: To determine maternal serum placental protein 13 (PP13) in normal pregnancy and preeclampsia. Methods: A prospective, longitudinal study with 41 normal pregnant women, 18 cases with preterm delivery or cervix insufficiency and 4 with ...
Bartz, Clemens, Chefetz, Ilana, Huppertz, Berthold, Meiri, Hamutal, Neumaier-Wagner, Peruka, Sammar, Marei   +5 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

THE EFFECTIVENESS OF THE OBSTETRIC PESSARY FOR THREATENING PRETERM BIRTH AND SHORT CERVIX

Медицинский совет, 2017
Preterm birth is one of the most important problems of modern obstetrics. The etiology of preterm birth is multifactorial, including the maternal and fetal complications, on the background of functionally vulnerable variants of many genes, therefore ...
O. N. Bespalova, G. S. Sargsyan
doaj   +1 more source

The impact of cervical conization size with subsequent cervical length changes on preterm birth rates in asymptomatic singleton pregnancies

Scientific Reports, 2021
The study aimed to explore the impact of cervical conization size (CCS) with subsequent cervical length (USCL) changes on preterm birth (PTB) rates in asymptomatic singleton pregnancies as compared to pregnancy outcomes in healthy women with an intact ...
Sergei V. Firichenko, Michael Stark, Ospan A. Mynbaev   +2 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra [PDF]

, 2018
Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration.
Alisio, Mariana, Altieri, Emma, Anderson, Monica, Barber, Sabrina, Burger, Tracy, Chubiz, Jessica, Diveley, Emily, England, Sarah K, Garcia-Uribe, Alejandro, Goldstein, Naomi, Helm, Kristi, Hu, Peng, Kramer, Christine, Li, Chiye, Ma, Jun, Macones, George A, Maslov, Konstantin, Maynard, Jennifer, McCarthy, Ronald, Meyenburg, Kaytelyn, Meyers, Karen, Muench, Lisa, Onwumere, Oji, Pizzella, Stephanie, Punyamurthy, Nina, Qu, Yuan, Shi, Junhui, Slaughter, Janessia, Stout, Molly J, Tuuli, Methodius, Wang, Lihong V, Zhao, Peinan   +31 more
core   +1 more source