Results 41 to 50 of about 3,454,166 (281)

Seismic Damage Quantification of RC Short Columns from Crack Images Using the Enhanced U-Net

open access: yesBuildings
It is of great importance to quantify the seismic damage of reinforced concrete (RC) short columns since they often experience severe damage due to likely excessive shear deformation.
Zixiao Chen   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Modeling of hydrogen effects on short crack propagation in a metastable austenitic stainless steel (X2CrNi19-11)

open access: yesMATEC Web of Conferences, 2018
The experimentally observed short fatigue crack growth rate of an uncharged specimen tested in air is compared with results obtained from specimens tested in 10 MPa hydrogen atmosphere and specimens previously charged with hydrogen.
Schippl Volker   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Hydrogen Embrittlement Mechanism in Fatigue Behavior of Austenitic and Martensitic Stainless Steels

open access: yesMetals, 2018
In the present study, the influence of hydrogen on the fatigue behavior of the high strength martensitic stainless steel X3CrNiMo13-4 and the metastable austenitic stainless steels X2Crni19-11 with various nickel contents was examined in the low and high
Sven Brück   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

About the Process of Metal Microfracture at Complex Stress State

open access: yesМеханика машин, механизмов и материалов, 2011
Here is presented the mathematical model described the volume microfracture of metals considering sequences of origin and grow of submicroscopic, microscopic and short cracks at complex stress state.
E.B. Zavoichinskaya
doaj  

Laboratory Characterization of The Load Transfer-Crack Width Relation for Innovative Short Concrete Slabs Pavements

open access: yesThe Baltic Journal of Road and Bridge Engineering, 2020
Aggregate interlock is the dominant load transfer mechanism in non-dowelled Jointed Plain Concrete Pavements, as the innovative short concrete slabs.
Mauricio Pradena   +2 more
doaj   +1 more source

The crack kinking out of an interface [PDF]

open access: yesTheoretical and Applied Mechanics, 2005
Kinking of a plane strain crack out of an interface between the two dissimilar isotropic elastic materials is analyzed. Analysis is focused on the initiation of kinking and thus the segment of the crack leaving the interface is imagined to be short ...
Veljković Jelena M.
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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