Results 141 to 150 of about 1,229,463 (349)

Climate Fluctuations and Growing Sensitivity of Grape Production in Abruzzo (Central Italy) over the Past Sixty Years

open access: yesGeographies
The sensitivity of the agricultural production system to short- and long-term climate variations significantly affects the availability and prices of food resources, raising relevant issues of sustainability and food security.
Vincenzo Guerriero   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Belief and achievement: Examining the interplay between academic self-efficacy and weekly academic experiences

open access: yesActa Psychologica
Academic self-efficacy is theorised to foster favourable academic outcomes. While academic self-efficacy is believed to have a reciprocal relationship with academic mastery experiences, longitudinal naturalistic investigations are currently lacking ...
Nithila Ramesh, Patrick Klaiber
doaj   +1 more source

Understanding Short-Term and Long-Term Price Fluctuations of Main Staple Food Commodities in Aceh Province, Indonesia: An ARDL Investigation

open access: diamond, 2023
Hadi Arisyah Putra   +6 more
openalex   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

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