Results 231 to 240 of about 6,347,071 (258)
EvoSNR-Prom: Predicting promoters at single-nucleotide resolution with label-aware transfer learning of the pretrained EVO model. [PDF]
PLoS Comput BiolWei PJ, Zheng W, Gu Y, Zheng CH.
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The stability of m6A-marked transcripts is linked to cell identity in planarians. [PDF]
Nucleic Acids ResHöhn C +5 more
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How to Annotate and Submit a Short Linear Motif to the Eukaryotic Linear Motif Resource
Methods in Molecular Biology, 2020 Over the past few years, it has become apparent that approximately 35% of the human proteome consists of intrinsically disordered regions. Many of these disordered regions are rich in short linear motifs (SLiMs) which mediate protein-protein interactions.
Marc Gouw, Manjeet Kumar, Holger Dinkel
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SLiMDisc: short, linear motif discovery, correcting for common evolutionary descent. [PDF]
Nucleic Acids Research, 2006 Many important interactions of proteins are facilitated by short, linear motifs (SLiMs) within a protein's primary sequence. Our aim was to establish robust methods for discovering putative functional motifs.
Richard J. Edwards +2 more
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Journal of Proteome Research, 2022 International audienceCells express thousands of macromolecules, and their functioning relies on multiple networks of intermolecular interactions. These interactions can be experimentally determined at different spatial and temporal resolutions.
Victor REYS, Gilles Labesse
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The eukaryotic linear motif resource - 2018 update. [PDF]
Nucleic Acids Research, 2018 Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org)
Ziqi Deng, Benjamin Lang, Norman Davey
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Stressing the role of a short linear motif in ataxin-2 condensation
Molecular Cell, 2023Ataxin-2, an RNA-binding protein that is conserved across eukaryotes, is involved in stress granule assembly and age-associated neurodegenerative diseases. In this issue of Molecular Cell, Boeynaems et al.1 identify a short linear motif in ataxin-2 as a condensation switch, providing molecular insights into its essential role in cellular stress ...
Scheidt, Tom +3 more
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Attributes of short linear motifs
Molecular BioSystems, 2011Abstract Traditionally, protein–protein interactions were thought to be mediated by large, structured domains. However, it has become clear that the interactome comprises a wide range of binding interfaces with varying degrees of flexibility, ranging from rigid globular domains to disordered regions that natively lack structure ...
Davey NE +9 more
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Mimicry of Short Linear Motifs by Bacterial Pathogens: A Drugging Opportunity
Trends in Biochemical Sciences, 2020Bacterial pathogens have developed complex strategies to successfully survive and proliferate within their hosts. Throughout the infection cycle, direct interaction with host cells occurs. Many bacteria have been found to secrete proteins, such as effectors and toxins, directly into the host cell with the potential to interfere with cell regulatory ...
Hugo, Sámano-Sánchez, Toby J, Gibson
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