Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis [PDF]
Cells, 2022 Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for cancer initiation, progression, and invasion. This multistage process is based on a dense network of protein–protein interactions (PPIs) that become dysregulated as a
Candida Fasano +3 more
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Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2 [PDF]
Toxins, 2021 Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve ...
Caterina Peggion, Fiorella Tonello
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Short Linear Motifs Orchestrate Functioning of Human Proteins during Embryonic Development, Redox Regulation, and Cancer [PDF]
Metabolites, 2022 Short linear motifs (SLiMs) are evolutionarily conserved functional modules of proteins that represent amino acid stretches composed of 3 to 10 residues.
Susanna S. Sologova +3 more
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How different viruses perturb host cellular machinery via short linear motifs [PDF]
EXCLI Journal : Experimental and Clinical Sciences, 2023 The virus interacts with its hosts by developing protein-protein interactions. Most viruses employ protein interactions to imitate the host protein: A viral protein with the same amino acid sequence or structure as the host protein attaches to the host ...
Sobia Idrees +3 more
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Exploiting the endogenous yeast nuclear proteome to identify short linear motifs in vivo [PDF]
Cell Reports: Methods, 2023 Summary: Peptide-domain interactions mediated by short linear motifs (SLiMs) play crucial roles in cellular biology. The simplicity of SLiMs poses challenges in their computational identification.
Tanner M. Tessier +2 more
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Evolutionary Conserved Short Linear Motifs Provide Insights into the Cellular Response to Stress [PDF]
Antioxidants, 2022 Short linear motifs (SLiMs) are evolutionarily conserved functional modules of proteins composed of 3 to 10 residues and involved in multiple cellular functions.
Sergey P. Zavadskiy +4 more
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Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs [PDF]
Nature Communications, 2023 Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions. Studies of motif-mediated interactions therefore provide insight into virus-host dependencies, and reveal targets for therapeutic intervention.
Filip Mihalič +21 more
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Short linear motifs—underexplored players driving Toxoplasma gondii infection [PDF]
Microbiology SpectrumPathogens infect hosts by interacting with host proteins and exploiting their functions to their advantage. Short linear motifs, small functional regions within intrinsically disordered protein regions, are common mediators of host-pathogen protein ...
Jesús Alvarado Valverde +5 more
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Diversity of short linear interaction motifs in SARS-CoV-2 nucleocapsid protein
mBio, 2023 Molecular mimicry of short linear interaction motifs has emerged as a key mechanism for viral proteins binding host domains and hijacking host cell processes.
Peter Schuck, Huaying Zhao
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Decoding phospho-regulation and flanking regions in autophagy-associated short linear motifs [PDF]
Communications BiologyShort Linear Motifs (SLiMs) play a pivotal role in the interactions between intrinsically disordered proteins and their binding partners. SLiMs can undergo regulation through post-translational modifications, including phosphorylation.
Mattia Utichi +7 more
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