Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2 [PDF]
Toxins, 2021 Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve ...
Caterina Peggion, Fiorella Tonello
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Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo [PDF]
eLife, 2015 Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here,
Manon Baëza +8 more
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Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis [PDF]
Cells, 2022 Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for cancer initiation, progression, and invasion. This multistage process is based on a dense network of protein–protein interactions (PPIs) that become dysregulated as a
Candida Fasano +3 more
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How different viruses perturb host cellular machinery via short linear motifs [PDF]
EXCLI Journal : Experimental and Clinical Sciences, 2023 The virus interacts with its hosts by developing protein-protein interactions. Most viruses employ protein interactions to imitate the host protein: A viral protein with the same amino acid sequence or structure as the host protein attaches to the host ...
Sobia Idrees +3 more
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Exploiting the endogenous yeast nuclear proteome to identify short linear motifs in vivo [PDF]
Cell Reports: Methods, 2023 Summary: Peptide-domain interactions mediated by short linear motifs (SLiMs) play crucial roles in cellular biology. The simplicity of SLiMs poses challenges in their computational identification.
Tanner M. Tessier +2 more
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Evolutionary Conserved Short Linear Motifs Provide Insights into the Cellular Response to Stress [PDF]
Antioxidants, 2022 Short linear motifs (SLiMs) are evolutionarily conserved functional modules of proteins composed of 3 to 10 residues and involved in multiple cellular functions.
Sergey P. Zavadskiy +4 more
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Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs [PDF]
Nature Communications, 2023 Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions. Studies of motif-mediated interactions therefore provide insight into virus-host dependencies, and reveal targets for therapeutic intervention.
Filip Mihalič +21 more
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Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey. [PDF]
Frontiers in Microbiology, 2014 Short linear motifs are functional stretches of protein sequence that are of crucial importance for numerous biological processes by mediating protein-protein interactions.
Heini eRuhanen +13 more
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Decoding phospho-regulation and flanking regions in autophagy-associated short linear motifs [PDF]
Communications BiologyShort Linear Motifs (SLiMs) play a pivotal role in the interactions between intrinsically disordered proteins and their binding partners. SLiMs can undergo regulation through post-translational modifications, including phosphorylation.
Mattia Utichi +7 more
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Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition [PDF]
eLife, 2022 Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes methylesterase activation upon binding to the PP2A core enzyme.
Yitong Li +9 more
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