Results 21 to 30 of about 197,713 (247)

Host sequence motifs shared by HIV predict response to antiretroviral therapy [PDF]

BMC Medical Genomics, 2009
Background The HIV viral genome mutates at a high rate and poses a significant long term health risk even in the presence of combination antiretroviral therapy.
Ungar Lyle, Evans Perry, Dampier William, Tozeren Aydin   +3 more
doaj   +2 more sources

HH-MOTiF: de novo detection of short linear motifs in proteins by Hidden Markov Model comparisons. [PDF]

Nucleic Acids Res, 2017
Short linear motifs (SLiMs) in proteins are self-sufficient functional sequences that specify interaction sites for other molecules and thus mediate a multitude of functions. Computational, as well as experimental biological research would significantly benefit, if SLiMs in proteins could be correctly predicted de novo with high sensitivity.
Prytuliak R, Volkmer M, Meier M, Habermann BH.   +3 more
europepmc   +12 more sources

A correlated motif approach for finding short linear motifs from protein interaction networks [PDF]

BMC Bioinformatics, 2006
Background An important class of interaction switches for biological circuits and disease pathways are short binding motifs. However, the biological experiments to find these binding motifs are often laborious and expensive.
Hugo Willy, Tan Soon-Heng, Sung Wing-Kin, Ng See-Kiong   +3 more
doaj   +4 more sources

The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking [PDF]

Cell Reports
Summary: Chlamydia trachomatis, a leading cause of bacterial sexually transmitted infections, creates a specialized intracellular replicative niche by translocation and insertion of a diverse array of effectors (Incs [inclusion membrane proteins]) into ...
Khavong Pha, Kathleen Mirrashidi, Jessica Sherry, Cuong Joseph Tran, Clara M. Herrera, Eleanor McMahon, Cherilyn A. Elwell, Joanne N. Engel   +7 more
doaj   +2 more sources

Enhancing prediction of short linear protein motifs with Wregex 3.0

Computational and Structural Biotechnology Journal
Short linear motifs (SLiMs) play an important role in protein-protein interactions. However, SLiM patterns are intrinsically permissive and result into many matches that occur just by chance, specially when targeting large datasets.
Gorka Prieto, Jose A. Rodríguez, Asier Fullaondo   +2 more
doaj   +4 more sources

Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder [PDF]

Frontiers in Pharmacology, 2015
Phosphorylation events that occur in response to the second messenger cAMP are controlled spatially and temporally by protein kinase A (PKA) interacting with A-kinase anchoring proteins (AKAPs).
Patrick J Nygren, Patrick J Nygren, John D. Scott, John D. Scott   +3 more
doaj   +2 more sources

Exploiting publicly available biological and biochemical information for the discovery of novel short linear motifs. [PDF]

PLoS ONE, 2011
The function of proteins is often mediated by short linear segments of their amino acid sequence, called Short Linear Motifs or SLiMs, the identification of which can provide important information about a protein function.
Ahmed Sayadi, Leonardo Briganti, Anna Tramontano, Allegra Via   +3 more
doaj   +2 more sources

Identification of Entry Factors Involved in Hepatitis C Virus Infection Based on Host-Mimicking Short Linear Motifs. [PDF]

PLoS Computational Biology, 2017
Host factors that facilitate viral entry into cells can, in principle, be identified from a virus-host protein interaction network, but for most viruses information for such a network is limited.
Austin W T Chiang, Walt Y L Wu, Ting Wang, Ming-Jing Hwang   +3 more
doaj   +2 more sources

Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs. [PDF]

Biochem J, 2022
Cellular function is based on protein–protein interactions. A large proportion of these interactions involves the binding of short linear motifs (SLiMs) by folded globular domains. These interactions are regulated by post-translational modifications, such as phosphorylation, that create and break motif binding sites or tune the affinity of the ...
Kliche J, Ivarsson Y.
europepmc   +4 more sources

Understanding protein multifunctionality: from short linear motifs to cellular functions. [PDF]

Cell Mol Life Sci, 2019
Moonlighting proteins perform multiple unrelated functions without any change in polypeptide sequence. They can coordinate cellular activities, serving as switches between pathways and helping to respond to changes in the cellular environment. Therefore, regulation of the multiple protein activities, in space and time, is likely to be important for the
Zanzoni A, Ribeiro DM, Brun C.
europepmc   +5 more sources