The SLiMDisc server: short, linear motif discovery in proteins [PDF]
Nucleic Acids Research, 2007 Short, linear motifs (SLiMs) play a critical role in many biological processes, particularly in protein-protein interactions. Overrepresentation of convergent occurrences of motifs in proteins with a common attribute (such as similar subcellular location
Davey, Norman E. +5 more
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Short linear motifs - ex nihilo evolution of protein regulation. [PDF]
Cell Commun Signal, 2015 Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) have been characterised.
Davey NE, Cyert MS, Moses AM.
europepmc +6 more sources
Understanding protein multifunctionality: from short linear motifs to cellular functions. [PDF]
Cell Mol Life Sci, 2019 Moonlighting proteins perform multiple unrelated functions without any change in polypeptide sequence. They can coordinate cellular activities, serving as switches between pathways and helping to respond to changes in the cellular environment. Therefore, regulation of the multiple protein activities, in space and time, is likely to be important for the
Zanzoni A, Ribeiro DM, Brun C.
europepmc +6 more sources
Profile-based short linear protein motif discovery [PDF]
BMC Bioinformatics, 2012 Background Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3–10 amino acids in length that are enriched in disordered regions of proteins.
Haslam Niall J, Shields Denis C
doaj +6 more sources
Attributes of short linear motifs
Molecular BioSystems, 2012 Traditionally, protein–protein interactions were thought to be mediated by large, structured domains. However, it has become clear that the interactome comprises a wide range of binding interfaces with varying degrees of flexibility, ranging from rigid ...
Holger Dinkel +29 more
core +4 more sources
The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking [PDF]
Cell ReportsSummary: Chlamydia trachomatis, a leading cause of bacterial sexually transmitted infections, creates a specialized intracellular replicative niche by translocation and insertion of a diverse array of effectors (Incs [inclusion membrane proteins]) into ...
Khavong Pha +7 more
doaj +2 more sources
Exploiting publicly available biological and biochemical information for the discovery of novel short linear motifs. [PDF]
PLoS ONE, 2011 The function of proteins is often mediated by short linear segments of their amino acid sequence, called Short Linear Motifs or SLiMs, the identification of which can provide important information about a protein function.
Ahmed Sayadi +3 more
doaj +3 more sources
Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder [PDF]
Frontiers in Pharmacology, 2015 Phosphorylation events that occur in response to the second messenger cAMP are controlled spatially and temporally by protein kinase A (PKA) interacting with A-kinase anchoring proteins (AKAPs).
Patrick J Nygren +3 more
doaj +2 more sources
Evidence for the concerted evolution between short linear protein motifs and their flanking regions. [PDF]
PLoS ONE, 2009 BACKGROUND: Linear motifs are short modules of protein sequences that play a crucial role in mediating and regulating many protein-protein interactions. The function of linear motifs strongly depends on the context, e.g. functional instances mainly occur
Claudia Chica +2 more
doaj +4 more sources
Identification of Entry Factors Involved in Hepatitis C Virus Infection Based on Host-Mimicking Short Linear Motifs. [PDF]
PLoS Computational Biology, 2017 Host factors that facilitate viral entry into cells can, in principle, be identified from a virus-host protein interaction network, but for most viruses information for such a network is limited.
Austin W T Chiang +3 more
doaj +2 more sources