Results 41 to 50 of about 6,300,587 (242)
SLiMScape: a protein short linear motif analysis plugin for Cytoscape [PDF]
BMC Bioinformatics, 2013 Abstract Background Computational protein short linear motif discovery can use protein interaction information to search for motifs among proteins which share a common interactor. Cytoscape provides a visual interface for protein networks but there is no streamlined way to rapidly visualize motifs in a network of ...
Kevin T. O'Brien +2 more
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Frontiers in Microbiology, 2014 Short linear motifs are functional stretches of protein sequence that are of crucial importance for numerous biological processes by mediating protein-protein interactions.
Heini eRuhanen +13 more
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Structural Details of BH3 Motifs and BH3-Mediated Interactions: an Updated Perspective
Frontiers in Molecular Biosciences, 2022 Apoptosis is a mechanism of programmed cell death crucial in organism development, maintenance of tissue homeostasis, and several pathogenic processes.
Valentina Sora +3 more
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Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome [PDF]
, 2013 A key signature of module exchange in the genome is phase symmetry of exons, suggestive of exon shuffling events that occurred without disrupting translation reading frame.
Kalmár, Lajos +2 more
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SLiMDisc: short, linear motif discovery, correcting for common evolutionary descent [PDF]
Nucleic Acids Research, 2006 Many important interactions of proteins are facilitated by short, linear motifs (SLiMs) within a protein's primary sequence. Our aim was to establish robust methods for discovering putative functional motifs. The strongest evidence for such motifs is obtained when the same motifs occur in unrelated proteins, evolving by convergence.
Davey, Norman E. +2 more
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Computational Investigation of Structural Interfaces of Protein Complexes with Short Linear Motifs [PDF]
Journal of Proteome Research, 2020 Abstract Protein complexes with short linear motifs (SLiMs) are known to play important regulatory functions in eukaryotes. In this investigation, I have studied the structures deposited in PDB with SLiMs. The structures Were grouped into three broad categories of protein-protein, protein-peptide and the rest as others.
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Communications Biology, 2023 ATP-independent molecular chaperones are important for maintaining cellular fitness but the molecular determinants for preventing aggregation of partly unfolded protein substrates remain unclear, particularly regarding assembly state and basis for ...
Gefei Chen +10 more
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A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes [PDF]
Autophagy, 2012 Elimination of defective mitochondria is essential for the health of long-lived, postmitotic cells. To gain insight into this process, we examined programmed mitochondrial clearance in reticulocytes. BNIP3L is a mitochondrial outer membrane protein that is required for clearance.
Ji, Zhang +5 more
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A Review of Functional Motifs Utilized by Viruses
Proteomes, 2016 Short linear motifs (SLiM) are short peptides that facilitate protein function and protein-protein interactions. Viruses utilize these motifs to enter into the host, interact with cellular proteins, or egress from host cells.
Haitham Sobhy
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The identification of short linear motif-mediated interfaces within the human interactome [PDF]
Bioinformatics, 2012 Abstract Motivation: Eukaryotic proteins are highly modular, containing multiple interaction interfaces that mediate binding to a network of regulators and effectors. Recent advances in high-throughput proteomics have rapidly expanded the number of known protein–protein interactions (PPIs); however, the molecular basis for the majority ...
Robert J. Weatheritt +4 more
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