Results 61 to 70 of about 197,713 (247)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Computational Investigation of Structural Interfaces of Protein Complexes with Short Linear Motifs [PDF]

Journal of Proteome Research, 2020
AbstractProtein complexes with short linear motifs (SLiMs) are known to play important regulatory functions in eukaryotes. In this investigation, I have studied the structures deposited in PDB with SLiMs. The structures Were grouped into three broad categories of protein-protein, protein-peptide and the rest as others.
openaire   +2 more sources

Fast and accurate discovery of degenerate linear motifs in protein sequences. [PDF]

PLoS ONE, 2014
Linear motifs mediate a wide variety of cellular functions, which makes their characterization in protein sequences crucial to understanding cellular systems.
Abdellali Kelil, Benjamin Dubreuil, Emmanuel D Levy, Stephen W Michnick   +3 more
doaj   +1 more source

Motifs in Temporal Networks

, 2016
Networks are a fundamental tool for modeling complex systems in a variety of domains including social and communication networks as well as biology and neuroscience. Small subgraph patterns in networks, called network motifs, are crucial to understanding
Benson, Austin R., Leskovec, Jure, Paranjape, Ashwin   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The identification of short linear motif-mediated interfaces within the human interactome [PDF]

Bioinformatics, 2012
Abstract Motivation: Eukaryotic proteins are highly modular, containing multiple interaction interfaces that mediate binding to a network of regulators and effectors. Recent advances in high-throughput proteomics have rapidly expanded the number of known protein–protein interactions (PPIs); however, the molecular basis for the majority ...
Weatheritt, R. J., Luck, K., Petsalaki, E., Davey, N. E., Gibson, T. J.   +4 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends [PDF]

Structure, 2017
Microtubule plus-end tracking proteins (+TIPs) are involved in virtually all microtubule-based processes. End-binding (EB) proteins are considered master regulators of +TIP interaction networks, since they autonomously track growing microtubule ends and recruit a plethora of proteins to this location.
Kumar, Anil, Manatschal, Cristina, Rai, Ankit, Grigoriev, Ilya, Degen, Miriam Steiner, Jaussi, Rolf, Kretzschmar, Ines, Prota, Andrea E, Volkmer, Rudolf, Kammerer, Richard A., Akhmanova, Anna, Steinmetz, Michel O.   +11 more
openaire   +4 more sources

Two Mycenaean Stirrup-jars from the Levant [PDF]

, 2015
A cache of artifacts, recovered in 2014 by the cultural heritage squadron of the Guardia di Finanza (Gruppo Tutela Patrimonio Archeologico of the Nucleo Polizia Tributaria di Roma), included two Mycenaean stirrup jars among the pottery illegally brought ...
SPAGNOLI, FEDERICA
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source