Diversity of short linear interaction motifs in SARS-CoV-2 nucleocapsid protein
mBio, 2023 Molecular mimicry of short linear interaction motifs has emerged as a key mechanism for viral proteins binding host domains and hijacking host cell processes.
Peter Schuck, Huaying Zhao
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Prediction of virus-host protein-protein interactions mediated by short linear motifs. [PDF]
BMC Bioinformatics, 2017 Table S4. Supplement information describing the previous files. (Supplement - Prediction of Virus-Host Protein-Protein interactions based on Short Linear Motifs.pdf) available at https://figshare.com/articles/Supplement_-_Prediction_of_Virus-Host_Protein-
Becerra A, Bucheli VA, Moreno PA.
europepmc +8 more sources
FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance [PDF]
Genetics and Molecular Biology, 2017 The FOXP subfamily is probably the most extensively characterized subfamily of the forkhead superfamily, playing important roles in development and homeostasis in vertebrates.
Lucas Henriques Viscardi +7 more
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Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders [PDF]
The Journal of Clinical InvestigationMultiple approaches have targeted voltage-gated sodium (Nav) channels for analgesia. In this issue of the JCI, Shin et al. identified a peptide aptamer, NaViPA1, carrying a short polybasic motif flanked by serine residues in a structurally disordered ...
Sulayman D. Dib-Hajj, Stephen G. Waxman
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Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling. [PDF]
Mol Cell, 2020 SummaryShort linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify. We harnessed unbiased systematic approaches for SLiM discovery to elucidate the regulatory network of calcineurin (CN)/PP2B, the Ca2+-activated phosphatase that ...
Wigington CP +20 more
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Resources to Discover and Use Short Linear Motifs in Viral Proteins. [PDF]
Trends Biotechnol, 2020 Viral proteins evade host immune function by molecular mimicry, often achieved by short linear motifs (SLiMs) of three to ten consecutive amino acids (AAs). Motif mimicry tolerates mutations, evolves quickly to modify interactions with the host, and enables modular interactions with protein complexes.
Hraber P +6 more
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Short linear motifs - ex nihilo evolution of protein regulation. [PDF]
Cell Commun Signal, 2015 Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) have been characterised. The increase in complexity of transcriptional, post-transcriptional and post-translational regulation in higher ...
Davey NE, Cyert MS, Moses AM.
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Profile-based short linear protein motif discovery [PDF]
BMC Bioinformatics, 2012 Background Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3–10 amino acids in length that are enriched in disordered regions of proteins.
Haslam Niall J, Shields Denis C
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Short Linear Motifs Orchestrate Functioning of Human Proteins during Embryonic Development, Redox Regulation, and Cancer [PDF]
Metabolites, 2022 Short linear motifs (SLiMs) are evolutionarily conserved functional modules of proteins that represent amino acid stretches composed of 3 to 10 residues.
Susanna S. Sologova +3 more
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SLiMSearch 2.0: biological context for short linear motifs in proteins. [PDF]
Nucleic Acids Res, 2011 Short, linear motifs (SLiMs) play a critical role in many biological processes. The SLiMSearch 2.0 (Short, Linear Motif Search) web server allows researchers to identify occurrences of a user-defined SLiM in a proteome, using conservation and protein disorder context statistics to rank occurrences.
Davey NE +3 more
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