Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling. [PDF]
Mol Cell, 2020 Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify.
Wigington CP +20 more
europepmc +8 more sources
Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition [PDF]
eLife, 2022 Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes methylesterase activation upon binding to the PP2A core enzyme.
Yitong Li +9 more
doaj +4 more sources
SLiMSearch 2.0: biological context for short linear motifs in proteins. [PDF]
Nucleic Acids Res, 2011 Short, linear motifs (SLiMs) play a critical role in many biological processes. The SLiMSearch 2.0 (Short, Linear Motif Search) web server allows researchers to identify occurrences of a user-defined SLiM in a proteome, using conservation and protein ...
Davey NE +3 more
europepmc +9 more sources
Enhancing prediction of short linear protein motifs with Wregex 3.0 [PDF]
Computational and Structural Biotechnology JournalShort linear motifs (SLiMs) play an important role in protein-protein interactions. However, SLiM patterns are intrinsically permissive and result into many matches that occur just by chance, specially when targeting large datasets.
Gorka Prieto +2 more
doaj +5 more sources
A correlated motif approach for finding short linear motifs from protein interaction networks [PDF]
BMC Bioinformatics, 2006 Background An important class of interaction switches for biological circuits and disease pathways are short binding motifs. However, the biological experiments to find these binding motifs are often laborious and expensive.
Hugo Willy +3 more
doaj +7 more sources
FOXP in Tetrapoda: Intrinsically Disordered Regions, Short Linear Motifs and their evolutionary significance [PDF]
Genetics and Molecular Biology, 2017 The FOXP subfamily is probably the most extensively characterized subfamily of the forkhead superfamily, playing important roles in development and homeostasis in vertebrates.
Lucas Henriques Viscardi +7 more
doaj +7 more sources
Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo [PDF]
eLife, 2015 Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here,
Manon Baëza +8 more
doaj +5 more sources
Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders [PDF]
The Journal of Clinical InvestigationMultiple approaches have targeted voltage-gated sodium (Nav) channels for analgesia. In this issue of the JCI, Shin et al. identified a peptide aptamer, NaViPA1, carrying a short polybasic motif flanked by serine residues in a structurally disordered ...
Sulayman D. Dib-Hajj, Stephen G. Waxman
doaj +4 more sources
Resources to Discover and Use Short Linear Motifs in Viral Proteins. [PDF]
Trends Biotechnol, 2020 Viral proteins evade host immune function by molecular mimicry, often achieved by short linear motifs (SLiMs) of three to ten consecutive amino acids (AAs). Motif mimicry tolerates mutations, evolves quickly to modify interactions with the host, and enables modular interactions with protein complexes.
Hraber P +6 more
europepmc +5 more sources
Computational identification and analysis of protein short linear motifs [PDF]
Frontiers in Bioscience, 2010 Short linear motifs (SLiMs) in proteins can act as targets for proteolytic cleavage, sites of post-translational modification, determinants of sub-cellular localization, and mediators of protein-protein interactions.
Davey, Norman E. +2 more
core +5 more sources