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Mimicry of Short Linear Motifs by Bacterial Pathogens: A Drugging Opportunity
Trends in Biochemical Sciences, 2020Bacterial pathogens have developed complex strategies to successfully survive and proliferate within their hosts. Throughout the infection cycle, direct interaction with host cells occurs. Many bacteria have been found to secrete proteins, such as effectors and toxins, directly into the host cell with the potential to interfere with cell regulatory ...
Hugo, Sámano-Sánchez, Toby J, Gibson
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Exploring Short Linear Motifs Using the ELM Database and Tools
Current Protocols in Bioinformatics, 2017AbstractThe Eukaryotic Linear Motif (ELM) resource is dedicated to the characterization and prediction of short linear motifs (SLiMs). SLiMs are compact, degenerate peptide segments found in many proteins and essential to almost all cellular processes. However, despite their abundance, SLiMs remain largely uncharacterized.
Gouw, M. +5 more
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Stressing the role of a short linear motif in ataxin-2 condensation
Molecular Cell, 2023Ataxin-2, an RNA-binding protein that is conserved across eukaryotes, is involved in stress granule assembly and age-associated neurodegenerative diseases. In this issue of Molecular Cell, Boeynaems et al.1 identify a short linear motif in ataxin-2 as a condensation switch, providing molecular insights into its essential role in cellular stress ...
Scheidt, Tom +3 more
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Prediction of Biological Protein-protein Interaction Types Using Short-Linear Motifs
Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics, 2013Protein-protein interactions (PPIs) play a key role in many biological processes and functions in living cells. Thus, identification, prediction, and analysis of PPIs are important aspects in molecular biology. We propose a computational model to predict biological PPI types using short-linear motifs (SLiMs).
Manish Pandit, Luis Rueda, Alioune Ngom
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Identifying Protein Short Linear Motifs by Position-Specific Scoring Matrix
2016Short linear motifs (SLiMs) play a central role in several biological functions, such as cell regulation, scaffolding, cell signaling, post-translational modification, and cleavage. Identifying SLiMs is an important step for understanding their functions and mechanism.
Chun Fang +3 more
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The Eukaryotic Linear Motif resource: 2022 release
Nucleic Acids Research, 2022Manjeet Kumar +2 more
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Use of viral motif mimicry improves the proteome-wide discovery of human linear motifs
Cell Reports, 2022Bishoy Wadie +2 more
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A new linear cyclin docking motif that mediates exclusively S‐phase CDK‐specific signaling
EMBO Journal, 2021Ilona Faustova, Marco Loog, Mihkel Örd
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Proceedings of the National Academy of Sciences of the United States of America, 2022
Frederic Sorgeloos +2 more
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Frederic Sorgeloos +2 more
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