Results 131 to 140 of about 6,300,587 (242)

Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant. [PDF]

Int J Mol Sci, 2022
Soorajkumar A, Alakraf E, Uddin M, Du Plessis SS, Alsheikh-Ali A, Kandasamy RK.   +5 more
europepmc   +1 more source

Stanford Linear Accelerator Center Annual Environmental Monitoring Report, January--December 1989

, 1990
This progress report discusses environmental monitoring activities at the Stanford Linear Accelerator Center for 1989. Topics include climate, site geology, site water usage, land use, demography, unusual events or releases, radioactive and ...
Stanford Linear Accelerator Center
core   +1 more source

Optimising intrinsic disorder prediction for short linear motif discovery

, 2019
Short linear motifs (SLiMs) are short protein regions, commonly only 3 - 10 amino acids in length, that are directly involved in protein-protein interactions. Identification of SLiMs is important for understanding fundamental processes involved in normal cellular function. SLiMs interact with their partnering proteins with low affinity. This makes them
openaire   +2 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Short Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions

BMC Genomics, 2008
Background Protein interactions are essential for most cellular functions. Interactions mediated by domains that appear in a large number of proteins are of particular interest since they are expected to have an impact on diversities of cellular ...
Chen Zhengjun, Uversky Vladimir N, Ren Siyuan, Dunker A Keith, Obradovic Zoran   +4 more
doaj   +1 more source

ELM—the database of eukaryotic linear motifs [PDF]

, 2017
Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell.
Steinmetz, Michel O., Meiselbach, Heike, Toedt, Grischa, Schroeter, Christian, Van Roey, Kim, Haslam, Niall, Uyar, Bora, Schmidt, Tobias, Seiler, Markus, Hammer, Maria, Altenberg, Brigitte, Luck, Katja, Gibson, Toby J., Diella, Francesca, Jehl, Peter, Dinkel, Holger, Dymecka, Magdalena, Chatr-aryamontri, Andrew, Chica, Claudia, Weatheritt, Robert J., Budd, Aidan, Via, Allegra, Grebnev, Gleb, Davey, Norman E., McGuigan, Caroline, Jödicke, Lisa, Dammert, Marcel A., Edwards, Richard J., Michael, Sushama   +28 more
core  

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Investigating the eukaryotic host-like SLiMs in microbial mimitopes and their potential as novel drug targets for treating autoimmune diseases

Frontiers in Microbiology, 2022
Anjali Garg, Neelja Singhal, Manish Kumar   +2 more
doaj   +1 more source