Results 111 to 120 of about 197,713 (247)

Hierarchical Chain Model of Spider Capture Silk Elasticity

, 2005
Spider capture silk is a biomaterial with both high strength and high elasticity, but the structural design principle underlying these remarkable properties is still unknown. It was revealed recently by atomic force microscopy that, an exponential force--
C. Branden, F. Vollrath, H. Lu, J. F. Marko, J. M. Gosline, K. E. van Holde, K. M. Bonthrone, N. Becker, P. A. Guerette, S. B. Smith, Y. Zhang   +10 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Belief-propagation algorithm and the Ising model on networks with arbitrary distributions of motifs

, 2012
We generalize the belief-propagation algorithm to sparse random networks with arbitrary distributions of motifs (triangles, loops, etc.). Each vertex in these networks belongs to a given set of motifs (generalization of the configuration model).
A. K. Hartmann, A. V. Goltsev, B. J. Frey, C. Berge, J. F. F. Mendes, J. M. Mooij, J. Pearl, J. S. Yedidia, R. J. Baxter, S. N. Dorogovtsev, S. N. Dorogovtsev, S. N. Dorogovtsev, S. Yoon   +12 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Structural Insights into WY Domain SLiM-Containing Conserved RxLR Effectors: A Case Study of Five Important Phytophthora Species

Molecular Plant-Microbe Interactions
Pathogenicity in Phytophthora species is in part underpinned by a sophisticated arsenal of RxLR effectors, which function as molecular determinants of host immune manipulation.
B. C. Salasini, J. Chepsergon, C. I. Nxumalo, L. N. Moleleki   +3 more
doaj   +1 more source

Large-scale inference and graph theoretical analysis of gene-regulatory networks in B. stubtilis

, 2006
We present the methods and results of a two-stage modeling process that generates candidate gene-regulatory networks of the bacterium B. subtilis from experimentally obtained, yet mathematically underdetermined microchip array data.
Albert, Anshuman Gupta, Barabasi, Christiansen, Christiansen, Claire Christensen, Costas D. Maranas, Csete, Dauner, Dauner, Dauner, Dauner, Dauner, D’Haeseleer, Gardner, Gavin, Giot, Guelzim, Gupta, Hartemink, Ho, Holter, Ito, Jeong, Kashtan, Latora, Latora, Lee, Li, Luscombe, Mangan, Mangan, Ma’ayan, Milo, Newman, Oltvai, Réka Albert, Sauer, Shen-Orr, Uetz, Vazquez, Yeung, Zaslaver   +42 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins

Microbiome, 2017
Background Fusobacterium nucleatum is a gram-negative anaerobic species residing in the oral cavity and implicated in several inflammatory processes in the human body. Although F.
Andreas Zanzoni, Lionel Spinelli, Shérazade Braham, Christine Brun   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source