Results 101 to 110 of about 197,713 (247)

Contextual Motifs: Increasing the Utility of Motifs using Contextual Data

, 2017
Motifs are a powerful tool for analyzing physiological waveform data. Standard motif methods, however, ignore important contextual information (e.g., what the patient was doing at the time the data were collected).
Bailey T. L., Esbroeck A. Van, Esbroeck A. Van, Hoffman M. D., Lin J., Liu J. S., Murphy K. P., Saria S., Saria S., Vahdatpour A.   +9 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Definition and Discovery of Tandem SH3-Binding Motifs Interacting with Members of the p47^phox-Related Protein Family

Biomolecules
SH3 domains are widespread protein modules that mostly bind to proline-rich short linear motifs (SLiMs). Most known SH3 domain-motif interactions and canonical or non-canonical recognition specificities are described for individual SH3 domains.
Zsofia E. Kalman, Tamas Lazar, Laszlo Dobson, Rita Pancsa   +3 more
doaj   +1 more source

Analysis of Three-Dimensional Protein Images [PDF]

, 1997
A fundamental goal of research in molecular biology is to understand protein structure. Protein crystallography is currently the most successful method for determining the three-dimensional (3D) conformation of a protein, yet it remains labor intensive ...
Baxter, K., Fortier, S., Glasgow, J., Leherte, L., Steeg, E.   +4 more
core   +2 more sources

Machine Learning in Electronic Quantum Matter Imaging Experiments

, 2019
Essentials of the scientific discovery process have remained largely unchanged for centuries: systematic human observation of natural phenomena is used to form hypotheses that, when validated through experimentation, are generalized into established ...
Ch'ng, K., Davis, J. C. Séamus, Edkins, S. D., Eisaki, H., Fujita, K., Hamidian, M. H., Khatami, E., Kim, Eun-Ah, Mesaros, A., Uchida, S., Zhang, Yi   +10 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Prediction of Calmodulin-Binding Proteins Using Short-Linear Motifs

, 2017
Prediction of Calmodulin-binding (CaM-binding) proteins plays a very important role in the fields of biology and biochemistry, because Calmodulin binds and regulates a multitude of protein targets affecting different cellular processes. Short linear motifs (SLiMs), on the other hand, have been effectively used as features for analyzing protein-protein ...
Yixun Li, Mina Maleki, Nicholas J. Carruthers, Luis Rueda, Paul M. Stemmer, Alioune Ngom   +5 more
openaire   +2 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Physics-based evolution of transmembrane helices reveals mechanisms of cholesterol attraction

Nature Communications
The existence of linear cholesterol-recognition motifs in transmembrane domains has long been debated. Evolutionary molecular dynamics (Evo-MD) simulations—genetic algorithms guided by (coarse-grained) molecular force-fields–reveal that thermodynamic ...
Jeroen Methorst, Nino Verwei, Christian Hoffmann, Paweł Chodnicki, Roberto Sansevrino, Partha Pyne, Han Wang, Niek van Hilten, Dennis Aschmann, Alexander Kros, Loren Andreas, Jacek Czub, Dragomir Milovanovic, Herre Jelger Risselada   +13 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source