Results 61 to 70 of about 5,012 (228)

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Sequences, Anti-Sequences, Cycles, and Composite Novels: The Short Story in Genre Criticism

Journal of the Short Story in English, 2003
Le terme short story cycle s’applique à un recueil de nouvelles qui tient aussi du roman. Dans cet article, nombre d’ouvrages critiques récents consacrés à ce genre y sont discutés.
Suzanne Ferguson
doaj  

Smart Flexible Tactile Sensors: Recent Progress in Device Designs, Intelligent Algorithms, and Multidisciplinary Applications

Advanced Intelligent Discovery, EarlyView.
Flexible tactile sensors have considerable potential for broad application in healthcare monitoring, human–machine interfaces, and bioinspired robotics. This review explores recent progress in device design, performance optimization, and intelligent applications. It highlights how AI algorithms enhance environmental adaptability and perception accuracy
Siyuan Wang, Ming Dong, Rongrong Bao, Caofeng Pan   +3 more
wiley   +1 more source

SAANEN CARCASS QUANTITATIVE AND Longissimus dorsi QUALITATIVE CHARACTERISTICS OF FEEDING WITH PROTECTED FAT

Revista Caatinga, 2015
Twenty-eight uncastrated male Saanen goat kids, on a feedlot, with an average slaughter weight of 28 kg were used to evaluate the effects of feeding goat kids with metabolizable energy levels by the addition of protected fat to the diet.
ANA PAULA SILVA POSSAMAI, CLAUDETE REGINA ALCALDE, PAULA ADRIANA GRANDE, NATALIA HOLTZ ALVES PEDROSO MORA, FRANCISCO DE ASSIS FONSECA DE MACEDO   +4 more
doaj  

Feasibility Study of a Randomized Controlled Trial Investigating Renal Denervation as a Possible Treatment Option in Patients With Loin Pain Hematuria Syndrome

Canadian Journal of Kidney Health and Disease, 2020
Background: Loin Pain Hematuria Syndrome (LPHS) is a poorly understood clinical condition characterized by severe pain localized to the kidney but in the absence of identifiable urinary tract disease. There is no consensus on optimal treatment strategies
Bhanu Prasad, Maryam Jafari, Kaval Kour, Kunal Goyal, Francisco Garcia   +4 more
doaj   +1 more source

Musculoskeletal Phenotypes of 19 Patients With X‐Linked HNRNPH2‐Related Neurodevelopmental Disorder: A Prospective Case Series

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Detailed clinical phenotypes have been previously reported for 33 individuals with X‐linked HNRNPH2‐related neurodevelopmental disorder. Of these, 75% self‐reported a musculoskeletal abnormality, including hip dysplasia, scoliosis, kyphosis, lordosis, pes planus, arthritis, and missing spinous processes.
Ambar Garcia, Rachel Salazar, Nicole Holuba, Franklin E. Paulino, Michael G. Vitale, Jennifer M. Bain, Joshua Hyman   +6 more
wiley   +1 more source

A study on some phenotypic characteristics of the Karabakh horse in comparison with the Kurdish and Arabian horses [PDF]

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2007
In order to preserve genetic resources and revive local breeds within the country, some breed specifications of the Karabakh horse, an important local breed in Azarbaijan and Iran was studied.
payam mosapour, A.M Aghazade, Ali Hassanpour, H.A Mahpeikar, M Ebrahimi Hamed   +4 more
doaj  

Food restriction during pregnancy: effects on body condition and productive performance of primiparous rabbit does

World Rabbit Science, 2015
This study examined the effects of feed restriction at different stages of rabbit pregnancy on body condition and productive performance. Just after insemination, pregnant primiparous New Zealand White does were assigned to 4 groups (10/group): the ...
Laura Menchetti, Gabriele Brecchia, Raffaella Cardinali, Angela Polisca, Cristiano Boiti   +4 more
doaj   +1 more source

A Novel Splice Variant in ERGIC1 Causes Arthrogryposis Multiplex Congenita—Characterization Using Urine‐Derived Cells

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis multiplex congenita (AMC) is defined as the presence of joint contractures affecting at least two body regions at birth. Three different ERGIC1 variants have been reported in individuals with AMC. Here, we report on a 16‐year‐old male with a homozygous ERGIC1 c.250+1G>A variant that was classified as a variant of uncertain ...
Lauren Kerr, Paul McKay, Juliana Marulanda, Zenghui Wu, Reggie Hamdy, Sena Tavukcu, Noémi Dahan‐Oliel, Frank Rauch   +7 more
wiley   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source