Results 81 to 90 of about 11,813 (259)

Variable X-Ray Emission of the Planet Hosting T Tauri Star CI Tau

The Astronomical Journal
We report results of Chandra X-ray observations of CI Tau, a young magnetically active classical T Tauri star for which previous studies have reported periodic variability attributed to a massive planet in a short-period orbit.
Stephen L. Skinner, Manuel Güdel
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The TESS Ten Thousand Catalog: 10,001 Uniformly Vetted and Validated Eclipsing Binary Stars Detected in Full-frame Image Data by Machine Learning and Analyzed by Citizen Scientists

The Astrophysical Journal Supplement Series
The Transiting Exoplanet Survey Satellite (TESS) has surveyed nearly the entire sky in full-frame image mode with a time resolution of 200 s to 30 minutes and a temporal baseline of at least 27 days.
Veselin B. Kostov, Brian P. Powell, Aline U. Fornear, Marco Z. Di Fraia, Robert Gagliano, Thomas L. Jacobs, Julien S. de Lambilly, Hugo A. Durantini Luca, Steven R. Majewski, Mark Omohundro, Jerome Orosz, Saul A. Rappaport, Ryan Salik, Donald Short, William Welsh, Svetoslav Alexandrov, Cledison Marcos da Silva, Erika Dunning, Gerd Gühne, Marc Huten, Michiharu Hyogo, Davide Iannone, Sam Lee, Christian Magliano, Manya Sharma, Allan Tarr, John Yablonsky, Sovan Acharya, Fred Adams, Thomas Barclay, Benjamin T. Montet, Susan Mullally, Greg Olmschenk, Andrej Prša, Elisa Quintana, Robert Wilson, Hasret Balcioglu, Ethan Kruse, The Eclipsing Binary Patrol Collaboration   +38 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

The Persistent Missing Mass Problem in Planet Formation

The Astrophysical Journal Letters
Recent ground-based microlensing surveys suggest that our Galaxy may abound with small free-floating planets, potentially up to ∼21 such planets per star. We explore the implication of such possibility on the mass budget for planet formation.
Eve J. Lee, William DeRocco, Sam Hadden, B. Scott Gaudi   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Observations of Five Southern-hemisphere Cataclysmic Binary Stars

The Astronomical Journal
We present observations and analyses of five little-studied cataclysmic binary stars in the southern celestial hemisphere. Our new observations are from the South African Astronomical Observatory.
John R. Thorstensen, Annabelle E. Niblett, Shreya Gandhi, Lauren P. Zanarini, Gavin D. Goss, Arnav Singh, Divik Verma, Ryan C. Hickox, Emmanuel A. Durodola, Jiaqi Martin Ying   +9 more
doaj   +1 more source

Photometric Flickering of the CH CYG IN 2018

East European Journal of Physics
Photometric observations of the CH Cyg symbiotic star were conducted using the Zeiss 600 telescope at the ShAO (Shamakhy Astrophysical Observatory) between 06.07.2018 and 16.09.2018 over the course of 17 nights with the V-filter. The light curve for this
Kh.M. Mikailov, R.T. Mammadov
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source