Results 71 to 80 of about 20,149 (199)
The Journal of Physiology, EarlyView.Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti +2 more
wiley +1 more source
The classical “R-on-T” phenomenon
Indian Heart Journal, 2015 The polymorphic ventricular tachycardia (PVT) is uncommon arrhythmia with multiple causes and has been classified according to whether they are associated with long QT interval or normal QT.
Fatih Oksuz +9 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend We investigated the age‐ and sex‐related differences in the apicobasal repolarization gradient (ABRG) and evaluated their possible role inventricular arrhythmia vulnerability. Electrocardiographic imaging (ECGI) was performed in healthy subjects during sinus rhythm, and the average recovery time (RT) and activation–recovery ...
Vladimír Sobota +9 more
wiley +1 more source
14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses
The Journal of Physiology, EarlyView.Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley +1 more source
Repolarization adaptation to rapid change in heart rate in human models – a review
The Journal of Physiology, EarlyView.Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt +5 more
wiley +1 more source
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Nature Communications, 2017 Mutations in potassium and calcium channel genes have been associated with cardiac arrhythmias. Here, Jensen et al. show that an anion transporter chloride-bicarbonate exchanger AE3 is also responsible for the genetically-induced mechanism of cardiac ...
Kasper Thorsen +14 more
doaj +1 more source
Potential health benefits of cold‐water immersion: the central role of PGC‐1α
The Journal of Physiology, EarlyView.Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer +2 more
wiley +1 more source
Gene mutations in cardiac arrhythmias: a review of recent evidence in ion channelopathies
The Application of Clinical Genetics, 2013 Pi-Yin Hsiao,1 Hui-Chun Tien,2 Chu-Pin Lo,2 Jyh-Ming Jimmy Juang,3 Yi-Hsin Wang,2 Ruey J Sung41Institute of Life Sciences, National Central University, Taoyuan, Taiwan; 2Department of Financial and Computational Mathematics, Providence University ...
Hsiao PY +5 more
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