Results 151 to 160 of about 651,047 (310)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Distributed ledger technology in supply chains: a transaction cost perspective

, 2020
With the emergence of distributed ledger technology (DLT), numerous practitioners and researchers have proclaimed its beneficial impact on supply chain transactions in the future.
Roeck, Dominik, Sternberg, Steen-Henrik, Hofmann, Erik   +2 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Physico-chemical properties of milk and butter along the supply chains in smallholder dairy productions systems in Southern Ethiopia

Discover Food
This study addresses the lack of comprehensive evaluations of the physico-chemical quality of raw milk and major dairy products, such as butter across supply chains and dairy production systems (DPSs) in Southern Ethiopia.
Tsedey Azeze, Mitiku Eshetu, Tesfemariam Berhe, Zelalem Yilma   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The organisation of short supply chain by intermediaries.

, 2016
La thèse porte sur l’institutionnalisation de la proximité dans les marchés agroalimentaires et la place qu’occupent un certain nombre d’intermédiaires non économiques (salariés d’association, chercheurs, membres du ministère de l’Agriculture, conseillers des chambres d’agriculture) dans ce processus.
openaire   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

SHORT SUPPLY CHAINS

Ovaj rad prikazati će prednosti formiranja kratkih lanaca opskrbe na području LAG-a Posavina, području koje karakterizira izniman geoprometni položaj, kao i prirodna raznolikost, koja lokalnim proizvođačima poljoprivrednih proizvoda može osigurati ...
Čorak, Željka
core  

Do consumers support farmers and food supply chains promoting agrobiodiversity?

DIVINFOOD Practice abstractsAgrobiodiversity, including all the plant species and varieties used for food, is in decline. Just three crops account for 60% of the calories consumed worldwide: wheat, maize and rice (FAO).
Chiffoleau, Yuna
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source