Results 41 to 50 of about 359,037 (292)

Structured Shrinkage Priors

Journal of Computational and Graphical Statistics, 2023
In many regression settings the unknown coefficients may have some known structure, for instance they may be ordered in space or correspond to a vectorized matrix or tensor. At the same time, the unknown coefficients may be sparse, with many nearly or exactly equal to zero. However, many commonly used priors and corresponding penalties for coefficients
Maryclare Griffin, Peter D. Hoff
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Shrinkage and porosity in concretes produced with recycled concrete aggregate and rice husk ash

Revista IBRACON de Estruturas e Materiais, 2019
The admixture of recycled concrete aggregates (RCA) in new concretes is an interesting alternative in the efforts to mitigate environmental impacts. RCA may increase porosity and change properties of concretes.
V. CECCONELLO, B. R. C.SARTORI, M. P .KULAKOWSKI, C. S. KAZMIERCZAK, M. MANCIO   +4 more
doaj   +1 more source

Redistribution of internal forces in composite concrete girders made continuous vs. time [PDF]

Facta Universitatis. Series: Architecture and Civil Engineering, 2011
Research on the long-term behavior of composite concrete girders made continuous is presented in the paper. Concrete precast element is cracked under construction load.
Mašović Snežana, Stošić Saša, Pecić Nenad   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

WATER WITHIN LIGHTWEIGHT AGGREGATE CONCRETE AND ITS RELATION TO AUTOGENOUS SHRINKAGE [PDF]

, 2006
Autogenous shrinkage of lightweight aggregate concrete (LAC) has been investigated with the aims of studying if water within LAC is effective in preventing autogenous shrinkage as suggested by Bentz’s model.
Kristiawan, S A, Sangadji, Senot
core  

Analytical model tracing deformations in multistorey large timber panel building

Journal of Civil Engineering and Management, 2019
This paper deals with the deformation characteristics of wood-framed residential, small commercial and hotel buildings with sheathing. Recent building structures are based on large panel or modular technology, where elements in the form of diaphragms or ...
Jaroslaw Malesza, Czeslaw Miedzialowski, Leonas Ustinovichius   +2 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Free iron oxides modulate the surface properties of Benggang soil on Southern China: insights into erosive mechanisms

Frontiers in Environmental Science
Benggang, an erosional phenomenon located in southern China, exhibits distinctive characteristics that can have profound ecological and agricultural consequences as well as pose risks to human life.
Ling Jiang, Jie Chen, Le-Xing You, Fang-Shi Jiang, Yue Zhang, Jin-Shi Lin, Yan-He Huang   +6 more
doaj   +1 more source