Results 61 to 70 of about 343,438 (289)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Evaluation of longâ€term behaviour of composite timberâ€concrete structures according to EC
Technological and Economic Development of Economy, 2005 The objective of this work is the investigation of longâ€term behaviour of composite timberâ€concrete beams. Both ultimate and serviceability limit states have to be satisfied according to modern design codes, such as Eurocode 5.
Saulius Kavaliauskas +2 more
doaj +1 more source
Viruses, 2023 The COVID-19 pandemic has expanded fast over the world, affecting millions of people and generating serious health, social, and economic consequences.
Amani Almohaimeed, Jochen Einbeck
doaj +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Foods, 2019 Raspberries are one of Serbia’s best-known and most widely exported fruits. Due to market fluctuation, producers are looking for ways to preserve this fresh product.
Zoran Stamenković +6 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Numerical simulation on gradient cooling behavior of jumbo slab ingot [PDF]
China Foundry, 2013 Shrinkage porosity defect is often found in an air cooled jumbo steel ingot, which will influence the quality of the final rolled plates. In practical production, some rolled plates are frequently rejected due to the serious shrinkage porosity of the ...
Li Shengli, Jin Yonglong, Lü Nan
doaj
Comparative study of the influence of three types of fibre in the shrinkage of recycled mortar
Materiales de Construccion, 2018 Construction and demolition waste can be used as a substitution of natural aggregate in mortar and concrete elaboration. A poorer quality of recycled aggregates generally has negative impact on mortar properties.
P. Saiz-Martínez +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source