Results 51 to 60 of about 359,037 (292)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
From Minimax Shrinkage Estimation to Minimax Shrinkage Prediction
Statistical Science, 2012 Published in at http://dx.doi.org/10.1214/11-STS383 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org)
George, Edward I, Liang, Feng, Xu, Xinyi
openaire +4 more sources
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
Lightweight concrete for 3D-printing with internal curing agent for Portland cement hydration
Magazine of Civil Engineering, 2022 The development of 3D printing technology requires solving material science problems to ensure the rheology of concrete mixtures with controlled mobility and high retention of volume after extrusion and also the creation of favorable conditions for the ...
Inozemtcev Aleksandr +2 more
doaj +1 more source
Sequential Shrinkage Estimation
The Annals of Statistics, 1987 Let \(X_ 1,X_ 2,\ldots\) \((p\times 1)\) be i.i.d. \(N(\theta,\sigma^2V)\), with \(\theta\), \(\sigma\) unknown and \(V\) a known \(p\times p\) positive definite matrix. If it is decided to stop at stage \(n\) and \(\theta\) is estimated by \(\delta_ n=\delta_ n(X_ 1,\ldots,X_ n)\), then the loss will be \(L(\theta,\delta_ n)'Q(\delta_ n-\theta)+cn ...
Ghosh, Malay +2 more
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi +9 more
wiley +1 more source
Evaluation of longâ€term behaviour of composite timberâ€concrete structures according to EC
Technological and Economic Development of Economy, 2005 The objective of this work is the investigation of longâ€term behaviour of composite timberâ€concrete beams. Both ultimate and serviceability limit states have to be satisfied according to modern design codes, such as Eurocode 5.
Saulius Kavaliauskas +2 more
doaj +1 more source
Viruses, 2023 The COVID-19 pandemic has expanded fast over the world, affecting millions of people and generating serious health, social, and economic consequences.
Amani Almohaimeed, Jochen Einbeck
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source