Results 141 to 150 of about 78,383 (300)

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Space Shuttle booster thrust imbalance analysis

, 1985
An analysis of the Shuttle SRM thrust imbalance during the steady-state and tailoff portions of the boost phase of flight are presented. Results from flights STS-1 through STS-13 are included.
Bailey, W. R., Blackwell, D. L.
core   +1 more source

Conductive MOF-Modified Separator for Mitigating the Shuttle Effect of Lithium–Sulfur Battery through a Filtration Method

, 2019
Although there are plenty of merits for lithium–sulfur (Li–S) batteries, their undesired shuttle effect and insulated nature are hindering the practical applications.
Sheng Li (107261), Yangshen Chen (6447971), Yu Shen (10486), Jiansheng Wu (193208), Weina Zhang (128757), Jiayi Yang (408926), Cong Gao (276817), Yawen Xiao (5869316), Huanhuan Chen (706338), Bing Zheng (1426309), Fengwei Huo (1607113), Chen Chen (6544)   +11 more
core   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Shuttle Ku-band signal design study

, 1978
Carrier synchronization and data demodulation of Unbalanced Quadriphase Shift Keyed (UQPSK) Shuttle communications' signals by optimum and suboptimum methods are discussed.
Lindsey, W. C., Mckenzie, T. M., Braun, W. R.   +2 more
core   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

Shuttle/TDRSS modelling and link simulation study

, 1979
A Shuttle/TDRSS S-band and Ku-band link simulation package called LinCsim was developed for the evaluation of link performance for specific Shuttle signal designs. The link models were described in detail and the transmitter distortion parameters or user
Lindsey, W. C., Mckenzie, T. M., Biederman, L., Braun, W. R.   +3 more
core   +1 more source

Atomic‐Level CuOx‐CoOx‐Pd Interfacial Engineering Enables Hierarchical Synergy for High‐Efficiency ORR Pathways and Boosted Power Output in Alkaline Fuel Cells

Advanced Science, EarlyView.
Atomically dispersed CuOx (CPCu‐1) forms isolated Cu–Ov sites that enable defect‐mediated O2 activation and fast electron/proton transfer via interfacial synergy. In contrast, thick CuOx clusters (CPCu‐10) promote a surface‐adsorption‐controlled pathway with intermediate accumulation, highlighting a mechanism switch from interfacial activation to ...
Yang‐Yang Hsu, Ching‐Hua Fan, Kuan‐Wen Wang, Kuang‐Kuo Wang, Nozomu Hiraoka, Hirofumi Ishii, Ting‐Shan Chan, Po‐Chun Chen, Tsan‐Yao Chen   +8 more
wiley   +1 more source

Shuttle Suppression by Polymer-Sealed Graphene-Coated Polypropylene Separator

, 2018
"Shuttle effect" of lithium polysulfides (LiPS) leads to a poor performance and a short cycle life of the Li-S battery, thus limiting their practical application.
Ding, Yao, Wang, Fengchao, Wu, Hengan, Irfan Haider Abidi, Yao Ding, Wu, Ruizhe, Yanzi Yu, Fengchao Wang, Abidi, Irfan Haider, Minghao Zhuang, Zhuang, Minghao, Luo, Zhengtang, Ou, Xuewu, Yu, Yanzi, Hengan Wu, Ruizhe Wu, Abhishek Tyagi, Xuewu Ou, Zhengtang Luo, Tyagi, Abhishek   +19 more
core   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source