Results 111 to 120 of about 2,463,737 (363)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cluster Head-Based Cooperative Communication System for Efficient Energy Consumption in Swarm UAVs

IEEE Access
Demand for unmanned aerial vehicles (UAVs) has surged across diverse domains. Because UAV systems are battery-powered, their available energy is limited, which in turn constrains transmit power and thus communication range. To mitigate these constraints,
Donghyeon Kim, Yoseb Lee, Sangoh Park
doaj   +1 more source

A multi-zone model of the CFR engine : investigating cascading autoignition and octane rating

, 2011
Includes abstract.Includes bibliographical references (p. 103-109).The CFR engine is the standardised research engine used for the measurement of knock resistance of fuels through the Research Octane Number (RON) and Motor Octane Number(MON) tests.
Perumal, Marlan
core  

Research and development of Controlled Auto-Ignition (CAI) combustion in a 4-stroke multi-cylinder gasoline engine

, 2001
Copyright © 2001 SAE International. This paper is posted on this site with permission from SAE International. Further use of this paper is not permitted without permission from SAEControlled Auto-Ignition (CAI) combustion has been achieved in a ...
Nicos Ladommatos, Jian Li, Ladommatos, N, Ma, T, Li, J, Tom Ma, Hua Zhao, Zhao, H   +7 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The mechanism and effect factors of the combustion cycle‐to‐cycle variations in the spark ignition engine

Energy Science & Engineering
The combustion cycle‐to‐cycle variations (CCV) are the typical combustion phenomena in the internal combustion engine, which will not only affect the combustion efficiency, heat‐work conversion process, and emission formation in the cylinder, but also ...
Xiongbo Duan, Lining Feng, Yan Xia
doaj   +1 more source

1D model and rule-based calibration strategy to improve the performance of a turbocharged spark ignition engine over the whole engine map

Engineering Science and Technology, an International Journal
This paper deals with the performance improvement of a turbocharged spark ignition (SI) engine redesigned by adopting a refined 1D model and a rule-based (RB) calibration strategy.
Dino Pirrello, Luigi Teodosio, Fabio Berni   +2 more
doaj   +1 more source

Performance and Emissions of an Advanced Multi-Cylinder SI Engine Operating in Ultra-Lean Conditions [PDF]

, 2019
In this work the performance and noxious emissions of a prototype Spark Ignition (SI) engine, working in ultra-lean conditions, are investigated. It is a four-cylinder engine, having a very high compression ratio, and an active pre-chamber.
De Bellis Vincenzo, Bozza Fabio, Malfi Enrica, Teodosio Luigi, Tufano Daniela, Libert Cedric   +5 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

HYDROGEN ADDITION ON COMBUSTION AND EMISSION CHARACTERISTICS OF HIGH SPEED SPARK IGNITION ENGINE- AN EXPERIMENTAL STUDY [PDF]

Journal of Engineering Science and Technology, 2016
The present article aims at characterizing the combustion and emission parameters of a single cylinder high speed SI engine operating with different concentrations of hydrogen with gasoline fuel.
SHIVAPRASAD K. V. , P. R. CHITRAGAR, KUMAR G. N.   +2 more
doaj