Results 131 to 140 of about 16,195 (218)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Rebuttal to Correspondence on "Marine Scrubbers vs Low-Sulfur Fuels: A Comprehensive Well-To-Wake Life Cycle Assessment Supported by Measurements Aboard an Ocean-Going Vessel". [PDF]

Environ Sci Technol
Stathatou PM, Petrunia I, Barenthin T, Gotsis G, Jeffrey P, Fee C, Bergeron S, Tsezos M, Triantafyllou M, Gershenfeld N.   +9 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Mechanistic Insights into the Aging and Regeneration of SBS-Modified Asphalt Under Coastal Humid-Hot Environmental Conditions. [PDF]

Materials (Basel)
Chen CT, Alghabsha ATS, Cao X, Ren J.
europepmc   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Comparative Study of Wear Behavior of Hypereutectic Al-Si Piston Alloys Using Experimental and Numerical Methods. [PDF]

Materials (Basel)
Tashev A, Nikolov V, Dochev B, Dimova D, Kandeva M, Zagorski M.   +5 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Compositional Profiling of Carbonaceous Deposits From Failed Automotive Spark Plugs by Pyrolysis-Gas Chromatography Mass Spectrometry. [PDF]

Rapid Commun Mass Spectrom
Li Z, Cheng J, Zheng T, Liu B, Chen P.
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Speed and quality of complex strategic decisions. [PDF]

Proc Natl Acad Sci U S A
Sunde U, Zegners D, Strittmatter A.
europepmc   +1 more source