Results 141 to 150 of about 2,463,737 (363)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
New approaches to casting hypereutectic Al-Si alloys to achieve simultaneous refinement of primary silicon and modification of eutectic silicon [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityHypereutectic Al-Si alloys are of increasing interest for applications that require a combination of light weight and high wear resistance, such as pistons ...
Al-Helal, Kawther
core
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Ignition timing advance in the bi-fuel engine [PDF]
Transport Problems, 2009 The influence of ignition timing on CNG combustion process has been presented in this paper. A 1.6 liter SI engine has been tested in the special program. For selected engine operating conditions, following data were acquired: in cylinder pressure, crank
Marek FLEKIEWICZ
doaj
Simulation of the mixture preparation for an SI engine using multi-component fuels
, 2012 In order to reduce soot emissions and oil dilution of future SI-engines with direct injection a fundamental knowledge about wall film formation and its prediction is crucial. In the presented work, a turbocharged SI engine with direct injection was used
Heiß, Michael, Lauer, Thomas
core
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Results in EngineeringIn this study, the effects of different gasoline fuels are investigated to evaluate the performance and thermal efficiency of the gasoline engine using GT-Power Simulation. The study was conducted on a spark ignition engine, single cylinder, four-stroke (
Wisam Sattam Ghanim +2 more
doaj +1 more source
Experimental investigations on controlled auto-ignition combustion in a four-stroke gasoline engine
, 2001 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The effects of air and exhaust gas dilution on the CAI combustion of a range of fuels including three gasoline compositions, four primary reference fuels ...
Oakley, Aaron John, Oakley, A.J.
core
NUMERICAL COMPARISON OF AN ELECTRIC TURBO COMPOUND APPLIED TO A SI AND A CI ENGINE
, 2015 In a medium term scenario Internal Combustion Engine (ICE) downsizing and hybrid powertrain will represent the actual trend in vehicle technology to reduce fuel consumption and CO2 emission.
Stefano Frigo +8 more
core +1 more source