Results 111 to 120 of about 113,461 (351)

Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans-An Evolutionary Perspective. [PDF]

, 2019
The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Altman, Meghan O, Gagneux, Pascal
core   +1 more source

Role of sialic acid in brachyspira hyodysenteriae adhesion to pig colonic mucins [PDF]

, 2019
Infection with Brachyspira hyodysenteriae results in mucoid hemorrhagic diarrhea. This pathogen is associated with the colonic mucus layer, mainly composed of mucins. Infection regulates mucin O-glycosylation in the colon and increases mucin secretion as
Haesebrouck, Freddy, Linden, Sara, Quintana-Hayashi, Macarena P., Venkatakrishnan, Vignesh   +3 more
core   +2 more sources

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, EarlyView.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

A pH‐Responsive Synthetic Receptor for Switchable Binding of Carbohydrates

ChemPlusChem, EarlyView.
A diaminocarbazole macrocyclic receptor, designed for disaccharide recognition in water, exhibits distinct binding properties under alkaline versus neutral pH conditions. Carbohydrates are selectively recognized under alkaline conditions, whereas release of the bound guest occurs at physiological pH, effectively behaving as a pH‐switchable carbohydrate
Francesco Milanesi, Giona Corti, Andrea Baldi, Stefano Roelens, Oscar Francesconi   +4 more
wiley   +1 more source

Diagnostic Value of Sialic Acid in Pleural Effusion

Chinese Journal of Lung Cancer, 2010
The present study was conducted in 30 patients of malignant pleural effusion and 30 patients of non malignant pleural effusion. Pleural fluid and blood samples were taken at the time of admission, before starting any treatment.
S KHARB, S TANDON, A BANSAL
doaj  

Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus [PDF]

, 2014
: Several bacterial pathogens decorate their surfaces with sialic acid (Sia) residues within cell wall components or capsular exopolysaccharides. Sialic acid expression can promote bacterial virulence by blocking complement activation or by engagement of
Aaron Louie, AC Kuyl van der, AF Carlin, Ajit Varki, AL Lewis, AP Heikema, B Khatua, C Jones, C Liu, C Oetke, CE Rubens, E Vimr, ER Eichner, G Bao, G Kraal, G Kraal, H Cao, H Rempel, JM Haan den, Joshua Olson, JP Pereira, K Asano, L Martinez-Pomares, M Cornelissen, M Klaas, MB Marques, MR Wessels, MR York, N Vanderheijden, P Aichele, P Barral, P Seiler, Paul R. Crocker, PR Crocker, R Biesen, RE Mebius, RN Davidson, S Hannedouche, S Ram, S Weiman, T Junt, VG Monteiro, Victor Nizet, YS Xiong, Yung-Chi Chang, Z Zou   +45 more
core   +3 more sources

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, EarlyView.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infections

mBio
Porcine epidemic diarrhea virus (PEDV) is a globally distributed alphacoronavirus with economic importance that can cause severe watery diarrhea and even death in piglets.
Guanghao Guo, Mengjia Zhang, Zhuojia Xu, Peng Xi, Hongmei Zhu, Anouk Evers, Robert Jan Lebbink, Yifei Lang, Qigai He, Yao-Wei Huang, Tiehai Li, Berend Jan Bosch, Wentao Li   +12 more
doaj   +1 more source

Cloning of hemagglutinin (HA) protein of influenza A virus - Potential for sialic acid linkage discrimination [PDF]

, 2007
The initial step in infection of a cell by influenza A virus is the attachment of a virus particle to the target cell. This is accomplished by interaction of a glycoprotein, hemagglutinin (HA), found on the surface of the viral lipid membrane with cell ...
O'Connor, Brendan, Szczepaniak, Jakub
core  

Siglec receptors impact mammalian lifespan by modulating oxidative stress. [PDF]

, 2015
Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number
Fu, Xiaoming, Gagneux, Pascal, Garcia, Javier O, Garcia-Bingman, Andrea, Glass, Christopher K, Hazen, Stanley L, Heyser, Charles, Lin, Hongqiao, Läubli, Heinz, Pearce, Oliver MT, Romanoski, Casey E, Samraj, Annie N, Schwarz, Flavio, Secrest, Patrick, Varki, Ajit, Varki, Nissi, Wang, Xiaoxia   +16 more
core   +1 more source