Results 111 to 120 of about 5,135,061 (391)

Developing Biomaterial‐Based mRNA Delivery System for Lung Disease Treatment

Advanced Science, EarlyView.
Schematic illustration of biomaterial delivery mRNA for the treatment of lung diseases. Abstract Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery.
Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi   +7 more
wiley   +1 more source

Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation. [PDF]

, 2018
Given that unnatural sugar expression is metabolically achieved, the kinetics and disposition of incorporation can lend insight into the temporal and localization preferences of sialylation across the cell surface.
Haigh, Nathan E, Lebrilla, Carlito B, Liu, Mingqi, Maverakis, Emanual, Park, Diane Dayoung, Phoomak, Chatchai, Wong, Maurice, Wongkham, Sopit, Xu, Gege, Yang, Pengyuan   +9 more
core  

Cross-species infectivity of H3N8 influenza virus in an experimental infection in swine [PDF]

, 2015
Avian influenza A viruses have gained increasing attention due to their ability to cross the species barrier and cause severe disease in humans and other mammal species as pigs.
Amadori, Massimo, Baratelli, Massimiliano, Bilato, Dania, Chiapponi, Chiara, Córdoba, Lorena, Del Real, Gustavo, Foni, Emanuela, Fraile Sauce, Lorenzo José, Martín del Burgo, María Ángeles, Martínez, Jorge, Martínez-Orellana, Pamela, Montoya, Maria, Perlin, David S., Razzuoli, Elisabetta, Solórzano, Alicia   +14 more
core   +2 more sources

Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite

Nature Communications, 2016
Plasmodium knowlesi is a zoonotic parasite transmitted from macaques causing malaria in humans in Southeast Asia. Plasmodium parasites bind to red blood cell (RBC) surface receptors, many of which are sialylated. While macaques synthesize the sialic acid
Selasi Dankwa, Caeul Lim, A. Bei, R. Jiang, James R. Abshire, Saurabh D Patel, J. Goldberg, Yovany Moreno, M. Kono, J. Niles, M. Duraisingh   +10 more
semanticscholar   +1 more source

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, EarlyView.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source

Serum Total and Lipid Bound Sialic Acid Levels in Patients With Benign and Nonmelanom Malignant Skin Tumors [PDF]

Türk Biyokimya Dergisi, 2007
It has been reported that sialic acid containing oligosaccharides play an important rolein the adhesion between cancer cells and endothelial cells and metastatic potential of tumorcells is proportional to cell surface sialylation.
Beyhan Çakır, Cemal Aygıt, 1Bendigar Sunar, Selma Süer Gökmen,, Cemal Kazezoğlu,   +4 more
doaj  

Clinical Applica­tion of Sialic Acid I. On Serum Sialic Acid Contents in Patients [PDF]

, 1957
1) The contents of sialic acid in patients of various diseases sera were determined and increases of it were noticed in several diseases. 2) Sialic acid contents ranged between 50 and 100 mg./dl. in the normal serum.
Mori, Akitane, Onoda, Osamu, Suga, Masaaki, Yui, Yutaka   +3 more
core   +1 more source

Probing the CMP‐Sialic Acid Donor Specificity of Two Human β‐d‐Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O‐ and N‐Glycosylproteins

ChemBioChem, 2017
Sialylation of glycoproteins and glycolipids is catalyzed by sialyltransferases in the Golgi of mammalian cells, whereby sialic acid residues are added at the nonreducing ends of oligosaccharides.
Maxence Noel, P. Gilormini, Virginie Cogez, Nao Yamakawa, Dorothée Vicogne, C. Lion, C. Biot, Y. Guérardel, A. Harduin-Lepers   +8 more
semanticscholar   +1 more source

PLAUR+ Neutrophils Drive Anti‐PD‐1 Therapy Resistance in Patients with Hepatocellular Carcinoma by Shaping an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
The present study reveals that PLAUR+ neutrophils are enriched in immunotherapy non‐responders and correlate with poor prognosis. PLAUR+ neutrophils dictate immunotherapy resistance in hepatocellular carcinoma by forming an immunosuppressive tumor microenvironment characterized by CD8+ T cell exclusion and macrophage‐dependent immune suppression.
Shaoqing Liu, Yanzhao Zhou, Gaoxiang Li, Bingwen Zhu, Fang Wu, Jinxue Zhou, Xiaobing Chen, Bo Qin, Yanxia Gao, Fazhan Wang, Yong Jiang, Wenxin Xu   +11 more
wiley   +1 more source

Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction. [PDF]

, 2017
LuIII, a protoparvovirus pathogenic to rodents, replicates in human mitotic cells, making it applicable for use to kill cancer cells. This virus group includes H-1 parvovirus (H-1PV) and minute virus of mice (MVM).
Agbandje-McKenna, Mavis, Baker, Timothy S, Chipman, Paul, Cotmore, Susan, D'Abramo, Anthony, Geilen, Lorena, Halder, Sujata, Janssen, Mandy, Kurian, Justin, Mckenna, Robert, Misseldine, Adam, Pittman, Nikéa, Smith, J Kennon, Tattersall, Peter   +13 more
core   +3 more sources