Results 191 to 200 of about 113,461 (351)

CRISPR/Cas9‐Mediated Knockouts of the ALG3 and GNTI in N. benthamiana and Their Application to Pharmaceutical Production

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT N‐Glycosylation critically influences the efficacy, safety and pharmacokinetic properties of biopharmaceuticals. Plant expression platforms offer multiple advantages for the production of N‐glycosylated proteins, but their use is impeded by the presence of plant‐specific N‐glycan epitopes, which raise concerns of possible immunogenicity to ...
Dolgormaa Bataa   +7 more
wiley   +1 more source

Targeting Siglec-sialic acid checkpoint to reverse immune dysfunction mediated by plasmacytoid dendritic cells in myeloma. [PDF]

open access: yesBlood Adv
Ray A   +9 more
europepmc   +1 more source

Expression of Heart Development Protein With EGF‐Like Domains 1 (HEG1) Decorated With Low‐Sulfated Keratan Sulfate in Human Malignant Pleural Mesothelioma

open access: yesPathology International, EarlyView.
The purpose of this study is to investigate sulfation modification of the glycan structure decorating HEG1, one of the diagnostic markers of malignant pleural mesothelioma (MPM), in MPM. Immunohistochemical analysis reveals low‐sulfated keratan sulfate (KS) expression, recognized by 294‐1B1 and R‐10G, in MPM tissues with HEG1 expression.
Koki Nakashima   +9 more
wiley   +1 more source

Mapping the sialic acid-binding sites of LuIII and H-1 parvovirus. [PDF]

open access: yesJ Virol
Busuttil K   +13 more
europepmc   +1 more source

The role of acquired host immunity in periodontal diseases

open access: yesPeriodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane   +2 more
wiley   +1 more source

Sialic Acid-Containing Glycolipids Extend the Receptor Repertoire of Enterovirus-D68. [PDF]

open access: yesACS Infect Dis
Pereirinha da Silva AK   +9 more
europepmc   +1 more source

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