The schematic illustrates a workflow showing the current investigation using a boronic acid‐functionalized core–shell mesoporous silica‐TiO₂ (CSMS@TiO₂‐GLYMO‐APB) for N‐glycopeptide enrichment from biological samples, involving trypsin digestion, enrichment, deglycosylation with PNGase F, and subsequent mass spectrometry (MALDI‐TOF MS and Nano‐LC‐MS/MS)
Mohamed Adly Gab‐Allah+8 more
wiley +1 more source
Investigating the Utility of Leukocyte Sialic Acid Measurements in Lysosomal Free Sialic Acid Storage Disorder. [PDF]
Sabir MS+9 more
europepmc +1 more source
Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics
Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen+20 more
wiley +1 more source
Differences in the incorporation of N‐[acetyl‐3 H] mannosamine into the sialic acid of the major retinal gangliosides, studied in vivo [PDF]
Mathias Holm, Jan‐Eric Månsson
openalex +1 more source
A silicic acid adsorption method for the determination of ganglioside sialic acid
Robert H. McCluer, E.H. Coram, H.S. Lee
openalex +1 more source
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li+7 more
wiley +1 more source
Mapping the sialic acid-binding sites of LuIII and H-1 parvovirus. [PDF]
Busuttil K+13 more
europepmc +1 more source
Exploring Siglecs: Potential Modulators of Immune Cells in Food Allergy and Therapeutic Applications
Sialic acid‐binding immunoglobulin‐type lectins (Siglecs) are inhibitory receptors present on all immune cells involved in the allergic reaction. Currently, research is mostly focussed on targeting Siglecs on mast cells to possibly treat food allergies.
J. S. H. Schaapherder+5 more
wiley +1 more source
Sialic Acid-Containing Glycolipids Extend the Receptor Repertoire of Enterovirus-D68. [PDF]
Pereirinha da Silva AK+9 more
europepmc +1 more source
Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen+9 more
wiley +1 more source