Results 271 to 280 of about 69,641 (328)
Advanced Science, Volume 12, Issue 38, October 13, 2025.This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao +10 more
wiley +1 more source
Advanced Science, Volume 12, Issue 38, October 13, 2025.The present study reveals that PLAUR+ neutrophils are enriched in immunotherapy non‐responders and correlate with poor prognosis. PLAUR+ neutrophils dictate immunotherapy resistance in hepatocellular carcinoma by forming an immunosuppressive tumor microenvironment characterized by CD8+ T cell exclusion and macrophage‐dependent immune suppression.
Shaoqing Liu +11 more
wiley +1 more source
Computational and AI‐Driven Design of Hydrogels for Bioelectronic Applications
Advanced Electronic Materials, Volume 11, Issue 17, October 20, 2025.This review highlights the role of AI in advancing hydrogel design for bioelectronics, exploring natural, and synthetic gels tailored for applications like wound healing, biosensing, and tissue engineering. It emphasizes the synergy between hydrogels, electronics, and AI in creating responsive, multifunctional systems, showcasing recent innovations ...
Rebekah Finster +2 more
wiley +1 more source
Arthritis &Rheumatology, Volume 77, Issue 10, Page 1421-1432, October 2025.Objective Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes, and decreased nephrin production.
Rhea Bhargava +9 more
wiley +1 more source
Biotechnology and Bioengineering, Volume 122, Issue 10, Page 2724-2738, October 2025.ABSTRACT The rise in cancer, autoimmune, inflammatory, and infectious diseases in recent decades has led to a surge in the development of monoclonal antibodies (mAbs) therapies, now the most widely used family of biologics. To meet the growing global demand, biopharmaceutical industries are intensifying their production processes.
Ilona Metayer +7 more
wiley +1 more source
Cancer Medicine, Volume 14, Issue 19, October 2025.This study explores how antigen peptides and sugar chains affect the efficacy of glyco‐nanovaccines (iGN) in cancer immunotherapy. We show that antigen peptides, rather than sugar chains, are key to nanoparticle uptake and immune activation, with sialic acid‐modified iGN showing similar anti‐cancer efficacy to α‐mannose‐modified iGN in a mouse model ...
Narumi Harada +10 more
wiley +1 more source
Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies
Comprehensive Physiology, Volume 15, Issue 5, October 2025.Estrogen significantly modulates B‐cell immunity. We provide evidence for estrogen–B‐cell crosstalk (the estrogen–B‐cell axis) in regulating B‐cell function and shaping HIV acquisition, progression, and persistence, and highlight research gaps to guide hormone‐aware vaccines and therapies.
John Kasibante +3 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 4, Page 935-945, October 2025.Pharmacodynamic (PD) biomarkers can support biosimilarity assessment, potentially reducing the need for comparative clinical efficacy studies. This study aimed to characterize previously identified proteomic PD biomarker candidates for Interferon beta‐1a (IFNβ‐1a, n = 248) and pegylated IFNβ‐1a (pegIFNβ‐1a, n = 528) biologics at therapeutic doses, to ...
Lakshmi Manasa S. Chekka +15 more
wiley +1 more source
Anti‐SARS‐CoV‐2 Spike IgA2 Induces Inflammation by Human Macrophages
European Journal of Immunology, Volume 55, Issue 10, October 2025.Anti‐SARS‐CoV‐2 spike IgA drives inflammation in human macrophages through FcαRI‐Syk signaling. IgA2 immune complexes amplify cytokine production and alter glycolysis and mitochondrial function more potently than IgA1, indicating subclass‐specific immunometabolic reprogramming.
Lynn Mes +10 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 14, Issue 10, October 2025.ABSTRACT Tumour‐derived extracellular vesicles (tdEVs) have emerged as a promising representative of cancer manifestation that can be accessed non‐invasively through liquid biopsy. Selective examination of tdEVs requires their isolation, which relies on tumour‐specific surface markers. These markers are often identified using cancer cell lines cultured
Hugo P. Markus +4 more
wiley +1 more source