Results 291 to 300 of about 69,641 (328)

The Glycocalyx: Barriers and Opportunities at Cell–Cell Encounters

Proteoglycan Research, Volume 3, Issue 4, October 2025.
ABSTRACT The glycocalyx, a carbohydrate‐rich, gel‐like layer that coats every mammalian cell, is the first point of contact between cells in tissues. It therefore critically influences these encounters, impacting their mechanical, electrical, and chemical features that ultimately determines the outcome of cell–cell contacts.
Lucas C. Wyss, Spencer A. Freeman
wiley   +1 more source

Altered Glycosylation of PSA in Prostate Cancer Tissue

The Prostate, Volume 85, Issue 14, Page 1290-1298, October 2025.
ABSTRACT Background The glycosylation of proteins is commonly altered in cancer. This offers novel opportunities for cancer biomarker development. As prostate‐specific antigen (PSA) is a glycoprotein, identification of cancer‐specific PSA‐glycoforms is feasible. Such PSA‐glycoforms may provide valuable diagnostic and prognostic information. Methods PSA‐
Hannu Koistinen, Ruusu‐Maaria Merivirta, Timo‐Pekka Lehto, Anna Lempiäinen, Andrew Erickson, Ulf‐Håkan Stenman, Antti Rannikko, Tuomas Mirtti   +7 more
wiley   +1 more source

Tailored Metal‐Organic Framework‐Based Enzyme Hybrids: Immobilization Strategies, Improved Performance, and Biological Applications

Small Science, Volume 5, Issue 10, October 2025.
Metal‐organic frameworks (MOFs) offer versatile platforms for enzyme immobilization to overcome their inherent fragility. However, challenges such as restricted conformation and mass transfer limitations remain. Advances in precise MOF design can help overcome these obstacles, expanding their applicability across diverse fields, highlighting the ...
Xiang Xu, Jiacheng Wan, Jun Sun, Lina Wu, Jianping Lei   +4 more
wiley   +1 more source

Exploring Siglecs: Potential Modulators of Immune Cells in Food Allergy and Therapeutic Applications

Clinical &Experimental Allergy, Volume 55, Issue 10, Page 889-900, October 2025.
Sialic acid‐binding immunoglobulin‐type lectins (Siglecs) are inhibitory receptors present on all immune cells involved in the allergic reaction. Currently, research is mostly focussed on targeting Siglecs on mast cells to possibly treat food allergies.
J. S. H. Schaapherder, K. C. M. Verhoeckx, A. M. Ehlers, E. F. Knol, A. C. Knulst, L. A. P. M. Meulenbroek   +5 more
wiley   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, Volume 58, Issue 10, October 2025.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

Group A Streptococcus interacts with glycosaminoglycans via M proteins to modulate bacterial adherence in vitro

The FEBS Journal, Volume 292, Issue 20, Page 5540-5562, October 2025.
Interactions between bacteria and the extracellular matrix are a prerequisite for colonisation and infection. Phylogenetically diverse M proteins of group A Streptococcus (GAS) can selectively bind sulfated glycosaminoglycans with high affinity. M protein‐mediated recruitment of chondroitin sulfate and dermatan sulfate was shown to increase GAS ...
Tahnee B.‐D. McEwan, David M. P. De Oliveira, Emily K. Stares, Lauren E. Hartley‐Tassell, Christopher J. Day, Mark J. Walker, Michael P. Jennings, Ronald Sluyter, Martina L. Sanderson‐Smith   +8 more
wiley   +1 more source

Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship

Influenza and Other Respiratory Viruses, Volume 19, Issue 10, October 2025.
ABSTRACT Background Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against coronaviruses, clarify molecular effects via bioassays and docking, and explore structure–activity relationships.
Marcela Safratova, Yu‐Li Chen, Anna Hostalkova, Jakub Chlebek, Chung‐Fan Hsieh, Bing‐Hung Chen, Lucie Cahlikova, Stefan Kosturko, Anders Backlund, Jim‐Tong Horng, Tsong‐Long Hwang, Michal Korinek   +11 more
wiley   +1 more source

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Sialic Acid and Cancer

2014
Sialic acids are nine-carbon acidic monosaccharides found in terminal position of glycan chains. The sialylation of cell surface glycoconjugates is frequently altered in cancers, resulting in the expression of sialylated tumor-associated carbohydrate antigens that are specific markers for this disease.
Delannoy, Philippe, Julien, Sylvain
openaire   +3 more sources

Turnover of Free Sialic Acid, CMP‐Sialic Acid, and Bound Sialic Acid In Rat Brain

Journal of Neurochemistry, 1981
Abstract: Adult male rats were injected intraventricularly with N‐[3H]acetylmannosamine. After different time intervals the rats were killed and free sialic acid, CMP‐sialic acid, lipid‐ and protein‐bound sialic acid were isolated from brain and the specific radioactivities determined. Maximal specific radioactivity was reached after approximately 4 h
Wijnholt Ferwerda, Corrie M. Blok, Jan Heijlman   +2 more
openaire   +3 more sources

Sialic acids in fungi

Glycoconjugate Journal, 1999
The increasing number of reports on the presence of sialic acids in fungi (N-acetyl-, N-glycolyl- and 5,9-N,O-diacetylneuraminic acids) based on direct and indirect evidence warrants the present review. Formerly suggested as sialidase-sensitive sources of anionic groups at the cell surface of fungal species grown in chemically defined media (e.g ...
Roland Schauer, Luiz R. Travassos, Celuta S. Alviano   +2 more
openaire   +3 more sources