Results 301 to 310 of about 69,641 (328)
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Glycobiology, 1991
Cytidine 5'-monophosphosialic acid (CMP-sialic acid) is the activated form of sialic acid which is required for the biosynthesis of sialic acid-containing complex carbohydrates. Its discovery over 30 years ago by the laboratory of Dr Saul Roseman was a landmark in research dealing with the biosynthesis of these compounds.
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Cytidine 5'-monophosphosialic acid (CMP-sialic acid) is the activated form of sialic acid which is required for the biosynthesis of sialic acid-containing complex carbohydrates. Its discovery over 30 years ago by the laboratory of Dr Saul Roseman was a landmark in research dealing with the biosynthesis of these compounds.
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2019
Sialic acid (Sia) is involved in many biological activities and commonly occurs as a monosialyl residue at the nonreducing terminal end of glycoconjugates. The loss of activity of UDP-GlcNAc2-epimerase/ManNAc kinase, which is a key enzyme in Sia biosynthesis, is lethal to the embryo, which clearly indicates the importance of Sia in embryogenesis ...
Ken Kitajima, Chihiro Sato
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Sialic acid (Sia) is involved in many biological activities and commonly occurs as a monosialyl residue at the nonreducing terminal end of glycoconjugates. The loss of activity of UDP-GlcNAc2-epimerase/ManNAc kinase, which is a key enzyme in Sia biosynthesis, is lethal to the embryo, which clearly indicates the importance of Sia in embryogenesis ...
Ken Kitajima, Chihiro Sato
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The acidities of ascorbic and sialic acids
Journal of Chemical Education, 1970This note concerning the pKa's of ascorbic and sialic acids id presented since the compounds are of general interest to organic chemists and carbohydrate chemists as well as biochemists.
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[10] Determination of sialic acids
1994Publisher Summary This chapter describes isolation, purification, and characterization of monomeric sialic acids. There are two basic procedures for liberating sialic acids from glycosidic linkages—enzymatic and acid hydrolysis. In the former case, a variety of sialidases may be used, which differ in specificity for sialic acid linkage or species ...
Gerd Reuter, Roland Schauer
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Nonulosaminic Acid (Sialic Acid) in Protists
Nature, 1960NONULOSAMINIC ACID1, a group of simple and substituted 9-carbon sugars containing nitrogen, was thought restricted to mammals until it was found in the supernates of Escherichia coli and Citrobacter freundii cultures, but not in the supernates of Salmonella, Shigella, Pneumococcus or Bacillus cultures2.
Stuart A. Aaronson +3 more
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Polarographic Examination of Sialic Acids
Nature, 1961WE have investigated systematically the polarographic wave of neuraminic acid derivatives with a dropping-mercury electrode (m = 2.86 mgm./sec., t = 2.98 sec.). The existence of a sialic acid wave was anticipated from the fact that structurally related substances such as pyruvic acid1,2 and fructose3,4 give well-defined polarographic waves.
Barbara Robert +2 more
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Metabolism of Sialic Acids [PDF]
, 1982 The wide occurrence of sialic acids in nature is an indication of their great biological importance. As is described in other chapters in this book, the identification of the sialic acids was pioneered in several laboratories, while the biosynthetic mechanism of sialic acid formation was elucidated essentially by the work of Roseman’s and Warren’s ...
Roland Schauer, Anthony P. Corfield
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The distribution of sialic acids in nature
Comparative Biochemistry and Physiology, 1963Abstract 1. 1. The occurrence of sialic acids acids in nature has been studied. These acids are found in all species of Vertebrata, Cephalochorda, Hemichorda and Echinoderma tested. 2. 2. They are distributed sporadically in the phyla Platyhelminthes, Mollusca, Anthropoda and in bacteria.
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1982
The discovery and the widespread occurrence of the sialic acids in mammalian tissues (Blix 1936, Klenk 1941) has been correlated with a range of different biological functions (see chapter J) which continues to expand. Although the literature on sialic acid occurrence is large (Gottschalk 1960, Blix and Jeanloz 1969, Tuppy and Gottschalk 1972, Schauer ...
Roland Schauer, Anthony P. Corfield
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The discovery and the widespread occurrence of the sialic acids in mammalian tissues (Blix 1936, Klenk 1941) has been correlated with a range of different biological functions (see chapter J) which continues to expand. Although the literature on sialic acid occurrence is large (Gottschalk 1960, Blix and Jeanloz 1969, Tuppy and Gottschalk 1972, Schauer ...
Roland Schauer, Anthony P. Corfield
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Histochemistry of Sialic Acids
1982The aim of this chapter will be to escort the reader through the maze of histochemical methodology available for the location and identification of sialic acids and their variants in tissue sections. We shall confine most of our discussion to those forms of sialic acid which can be demonstrated histochemically, the methodology by which they may be ...
C. F. A. Culling, P. E. Reid
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