Results 31 to 40 of about 19,716 (237)

Multifaceted role of sialylation in prion diseases

Frontiers in Neuroscience, 2016
Mammalian prion or PrPSc is a proteinaceous infectious agent that consists of a misfolded, self-replicating state of a sialoglycoprotein called the prion protein or PrPC. Sialylation of the prion protein N-linked glycans was discovered more than 30 years
Ilia V Baskakov, Ilia V Baskakov, Elizaveta Katorcha, Elizaveta Katorcha   +3 more
doaj   +1 more source

Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies [PDF]

, 2013
Clostridium perfringens epsilon toxin (Etx) is a pore-forming toxin responsible for a severe and rapidly fatal enterotoxemia of ruminants. The toxin is classified as a category B bioterrorism agent by the U.S.
Abe, Abrami, Bhown, Bokori-Brown, Chassin, Cole, Davis, De Colibus, Diep, Dorca-Arevalo, Emsley, Finnie, Ivie, Ivie, Jin, Knight, Lavinder, Lonchamp, McClain, McCoy, McDonel, Minami, Miyamoto, Miyamoto, Miyata, Murshudov, Nagahama, Nagahama, Nagahama, Oyston, Parker, Payne, Pelish, Petit, Pflugrath, Popoff, Popoff, Recommendations of the CDC Strategic Planning Workgroup, Songer, Uzal, Winn   +40 more
core   +1 more source

Targeting CD22 for the Treatment of B-Cell Malignancies

ImmunoTargets and Therapy, 2021
Nikesh N Shah,1 Lubomir Sokol2 1Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; 2Department of Malignant Hematology, H.
Shah NN, Sokol L
doaj  

Early Destruction of the Extracellular Matrix around Parvalbumin-Immunoreactive Interneurons in Creutzfeldt-Jakob Disease

Neurobiology of Disease, 1999
GABA-interneurons immunoreactive (IR) for the calcium-binding protein parvalbumin are lost during the early stages of Creutzfeldt-Jakob disease (CJD) and diminution in their number may partially account for the neurological disturbances manifested in ...
Pavel V. Belichenko, Judith Miklossy, Brigitte Belser, Herbert Budka, Marco R. Celio   +4 more
doaj   +1 more source

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

Epitope mapping of anti-mouse podoplanin monoclonal antibody PMab-1

Biochemistry and Biophysics Reports, 2018
Mouse podoplanin (mPDPN) is a type I transmembrane sialoglycoprotein, which is expressed on lymphatic endothelial cells, podocytes of the kidney, and type I alveolar cells of the lung.
Shinji Yamada, Shunsuke Itai, Mika K. Kaneko, Satoru Konnai, Yukinari Kato   +4 more
doaj   +1 more source

The mouse–canine chimeric anti-dog podoplanin antibody P38B exerts antitumor activity in mouse xenograft models

Biochemistry and Biophysics Reports, 2019
Podoplanin (PDPN) is a type I transmembrane heavily glycosylated sialoglycoprotein that is expressed in normal tissues such as pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells.
Yukinari Kato, Tomokazu Ohishi, Manabu Kawada, Naoya Maekawa, Satoru Konnai, Shunsuke Itai, Shinji Yamada, Mika K. Kaneko   +7 more
doaj   +1 more source

Expression of the neural cell adhesion NCAM in endocrine cells of the ovary [PDF]

, 1991
In the adult mammalian ovary morphogenesis and differentiation processes are under hormonal control and, thus, occur in a highly regulated way during the sexual cycle.
Gratzl, Manfred, Lahr, G., Mayerhofer, Artur   +2 more
core   +1 more source

Exome sequencing and in vitro studies identified podocalyxin as a candidate gene for focal and segmental glomerulosclerosis [PDF]

, 2014
Our understanding of focal and segmental glomerulosclerosis (FSGS) has advanced significantly from the studies of rare, monogenic forms of the disease.
Barua, Moumita, Genovese, Giulio, Kaplan, Bernard S, Pollak, Martin R, Schlondorff, Johannes, Shieh, Eric   +5 more
core   +1 more source

Sialoglycoproteins of ejaculated human spermatozoa and seminal plasma [PDF]

International Journal of Andrology, 1984
Ejaculated human sperm were found to possess three major sialoglycoproteins with molecular weights of 30 000, 14 000 and 12 000 and one minor species of 18 000. Liquefied seminal plasma from normal donors contain two major sialoglycoproteins with molecular weights of 17 000 and 15 000 and two minor species of 70 000 and 54 000.
C, Wongkome, M, Chulavatnatol
openaire   +2 more sources